EFFECTS OF ISRADIPINE ON INDUCED-PARKINSON’S DISEASE IN RATS (SHORT COMMUNICATION)

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KOMEILI GHOLAMREZA; FARAJIAN MASHHADI FARZANEH

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Journal Paper

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Journal: Zahedan Journal of Research in Medical Sciences Year:2016 | Volume:18 | Issue:4 Page(s): 0-0

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Title

EFFECTS OF ISRADIPINE ON INDUCED-PARKINSON’S DISEASE IN RATS (SHORT COMMUNICATION)

Author(s)

KOMEILI GHOLAMREZA | FARAJIAN MASHHADI FARZANEH | Issue Writer Certificate

Keywords

ISRADIPINE

PARKINSON DISEASE

RAT

Abstract

Background: Parkinson’s disease is the second most common neurodegenerative disease in developed countries. Recent studies have showed that there is a relation between neuron loss in Parkinson’s disease and L-type calcium channel activity in pars compacta of substantia nigra. Therefore, it seems that calcium channel blockers can effect on this disease.Objectives: In this study, we evaluate the protective and therapeutic effects of ISRADIPINE on experimental Parkinson’s model in RATs.Materials and Methods: In this experimental study, 63 RATs were allocated randomly in seven group including: intact, control, sham operated, lesion and lesion treated by 0.1, 0.2 or 0.4 mg/kg dosage of ISRADIPINE. L-type calcium channel blocker, ISRADIPINE was subcutaneously injected to treated RATs in the doses of 0.1, 0.2 and 0.4 mg/kg/day, for four weeks, starting the day after a unilateral nigrostriatal 6-hydroxy dopamine (6-OHDA) lesion. Rotational tests with apomorphine and rigidity tests were conducted on all animal groups one week before the lesion experiments and four weeks after.Results: Administration of ISRADIPINE (0.1, 0.2 and 0.4 mg/kg/day for 4 weeks) decreased mean of rotation number and muscular rigidity score significantly compared with control group (P < 0.05).Conclusions: This study showed that ISRADIPINE has a therapeutic effect in a dose dependent manner on Parkinson’s disease in RATs.

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APA: Copy

KOMEILI, GHOLAMREZA, & FARAJIAN MASHHADI, FARZANEH. (2016). EFFECTS OF ISRADIPINE ON INDUCED-PARKINSON’S DISEASE IN RATS (SHORT COMMUNICATION). ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 18(4), 0-0. SID. https://sid.ir/paper/684449/en

Vancouver: Copy

KOMEILI GHOLAMREZA, FARAJIAN MASHHADI FARZANEH. EFFECTS OF ISRADIPINE ON INDUCED-PARKINSON’S DISEASE IN RATS (SHORT COMMUNICATION). ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2016;18(4):0-0. Available from: https://sid.ir/paper/684449/en

IEEE: Copy

GHOLAMREZA KOMEILI, and FARZANEH FARAJIAN MASHHADI, “EFFECTS OF ISRADIPINE ON INDUCED-PARKINSON’S DISEASE IN RATS (SHORT COMMUNICATION),” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 18, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/684449/en

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