The effects of adipose tissue-derived stem cells seeded onto the curcumin-loaded collagen scaffold in healing of experimentallyinduced oral mucosal ulcers in rat

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MARDANI MARYAM; Sadeghzadeh Azita; TANIDEH NADER; ANDISHEH TADBIR AZADEH; LAVAEE FATEMEH; Zarei Moein; MOAYEDI JAVAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2020 | Volume:23 | Issue:12 Page(s): 1618-1627

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

The effects of adipose tissue-derived stem cells seeded onto the curcumin-loaded collagen scaffold in healing of experimentallyinduced oral mucosal ulcers in rat

Author(s)

Keywords

ADSCs

Collagen

Curcumin

Experimental

Oral ulcers

Scaffold

Ulcer healing

Abstract

Objective(s): Various therapeutic approaches, including stem-cell-based strategies and tissue engineering, have been proposed for oral ulcerative lesions. We investigated the effects of adipose tissue-derived stem cells (ADSCs) seeded onto the Curcumin-loaded Collagen Scaffold in the mucosal healing of Oral ulcers in rats. Materials and Methods: The current Experimental study was conducted on 40 male Sprague-Dawley rats. Oral ulcers were created over both sides of buccal mucosa, and the rats were randomly divided into four equal groups: 1) an untreated group (negative control); 2) Teriadent-treated group (positive control); 3) group treated with Curcumin-loaded Collagen Scaffold; and 4) group received the ADSCs (3 × 106 cells) seeded onto the Curcumin-loaded Collagen Scaffold. Rats were sacrificed on 3rd and 7th day after ulceration for histopathological examination as well as measurement of tissue levels of myeloperoxidase (MPO), superoxide dismutase (SOD), and Interleukin-1 beta (IL-1β ) activity. Results: Compared with the negative control, the tissue levels of MPO and IL-1β were significantly decreased in all treated groups (P<0. 0001); however, the SOD activity was elevated (P<0. 0001). The highest SOD activity as well as the lowest MPO and IL-1β levels were observed in the ADSCs-Curcuminloaded Collagen Scaffold group. The Ulcer healing process at 3rd and 7th day follow-up was much more progressed in the ADSCs-Curcumin-loaded Collagen Scaffold group in comparison with the untreated group (P=0. 037 and P=0. 004, respectively). Conclusion: According to the findings of this study, ADSCs seeded onto the Curcumin-loaded Collagen Scaffold seems to have a promising potential for oral Ulcer healing applications.

Cites

Skin Stem Cells in Iran

References

No record.

Cite

APA: Copy

MARDANI, MARYAM, Sadeghzadeh, Azita, TANIDEH, NADER, ANDISHEH TADBIR, AZADEH, LAVAEE, FATEMEH, Zarei, Moein, & MOAYEDI, JAVAD. (2020). The effects of adipose tissue-derived stem cells seeded onto the curcumin-loaded collagen scaffold in healing of experimentallyinduced oral mucosal ulcers in rat. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(12), 1618-1627. SID. https://sid.ir/paper/685100/en

Vancouver: Copy

MARDANI MARYAM, Sadeghzadeh Azita, TANIDEH NADER, ANDISHEH TADBIR AZADEH, LAVAEE FATEMEH, Zarei Moein, MOAYEDI JAVAD. The effects of adipose tissue-derived stem cells seeded onto the curcumin-loaded collagen scaffold in healing of experimentallyinduced oral mucosal ulcers in rat. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(12):1618-1627. Available from: https://sid.ir/paper/685100/en

IEEE: Copy

MARYAM MARDANI, Azita Sadeghzadeh, NADER TANIDEH, AZADEH ANDISHEH TADBIR, FATEMEH LAVAEE, Moein Zarei, and JAVAD MOAYEDI, “The effects of adipose tissue-derived stem cells seeded onto the curcumin-loaded collagen scaffold in healing of experimentallyinduced oral mucosal ulcers in rat,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 12, pp. 1618–1627, 2020, [Online]. Available: https://sid.ir/paper/685100/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops