مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

EFFECT OF PERSIAN SAGE (SALVIA RHYTIDIA) EXTRACT ON HISTOMORPHOMETRIC CHANGES OF CEREBRAL CORTEX AND HIPPOCAMPUS FOLLOWING ISCHEMIA-REPERFUSION INJURIES IN RAT

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Abstract

 Background: In the present study the effect of SALVIA RHYTIDIA extract on thickness of CEREBRAL CORTEX and hippocampal regions following ISCHEMIA-REPERFUSION (IR) injuries is evaluated.Objectives: In the present study the extract of S. rhytidia, an endemic plant from south eastern of Iran, was used to prevent IR injuries induced in CEREBRAL CORTEX and HIPPOCAMPUS of rats.Materials and Methods: In this cross-sectional study, 35 male healthy Wistar rats between 250 - 350 g were randomly divided into 7groups of 5 rats. Control group (A), ischemic groups (B, D, E, F, G) that left common carotid and left vertebral arteries were occluded for 10 minutes. Group D received S. rhytidia extract (3.2 mg/kg) and group E received silymarin (50 mg/kg), a chemical drug which is used for reducing oxidative stress, 2 hours after ischemia, whereas group F received S. rhytidia extract (3.2 mg/kg) and group G received silymarin (50 mg/kg), 72, 48, 24 and0hours before ischemia. Group B received no drug and sham group (C) received normal saline (NS) without ischemia. After 24 hours reperfusion, the brains of rats were prepared for histological studies and the data were analyzed using one way ANOVA and Duncan as posthoc test.Results: IR resulted in decrease in thickness of the CEREBRAL CORTEX, CA1 and CA2 regions of the HIPPOCAMPUS in groups B, D and E compared to control (P< 0.05). But no significant decrease observed in thickness of the CEREBRAL CORTEX and all hippocampal regions in groups C, F, G and CA3 and dentate gyrus regions of the HIPPOCAMPUS in groups B, D and E compared to control.Conclusions: This study showed that S. rhytidia extract can protect the forebrain from IR injuries due to antioxidative effect of the drug.

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    APA: Copy

    HAGHJOO, RAHIL, & TADJALLI, MINA. (2016). EFFECT OF PERSIAN SAGE (SALVIA RHYTIDIA) EXTRACT ON HISTOMORPHOMETRIC CHANGES OF CEREBRAL CORTEX AND HIPPOCAMPUS FOLLOWING ISCHEMIA-REPERFUSION INJURIES IN RAT. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 18(2), 0-0. SID. https://sid.ir/paper/685214/en

    Vancouver: Copy

    HAGHJOO RAHIL, TADJALLI MINA. EFFECT OF PERSIAN SAGE (SALVIA RHYTIDIA) EXTRACT ON HISTOMORPHOMETRIC CHANGES OF CEREBRAL CORTEX AND HIPPOCAMPUS FOLLOWING ISCHEMIA-REPERFUSION INJURIES IN RAT. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2016;18(2):0-0. Available from: https://sid.ir/paper/685214/en

    IEEE: Copy

    RAHIL HAGHJOO, and MINA TADJALLI, “EFFECT OF PERSIAN SAGE (SALVIA RHYTIDIA) EXTRACT ON HISTOMORPHOMETRIC CHANGES OF CEREBRAL CORTEX AND HIPPOCAMPUS FOLLOWING ISCHEMIA-REPERFUSION INJURIES IN RAT,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 18, no. 2, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/685214/en

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