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Information Journal Paper

Title

A double-blind placebo-controlled randomized trial of oral saffron in the treatment of rheumatoid arthritis

Pages

  332-342

Abstract

 Objective: Recently, Saffron (Crocus sativus L. from the Iridaceae family) has been characterized by its antioxidant, anti-inflammatory and analgesic effects. This study aimed to evaluate the effect of Saffron on disease activity in patients with Rheumatoid arthritis (RA). Materials and Methods: This is a double-blind, placebo-controlled, randomized Clinical trial (RCT) performed on 55 newly-diagnosed RA patients without previous treatment, who were randomly divided into intervention (included 28 cases) and control groups (consisted of 27 individuals). Standard therapy including prednisolone, oral methotrexate, folic acid, vitamin D, calcium, and alendronate, was administered similarly in both groups. Patients received a 100 mg Saffron pill/day (pure Saffron powder) or placebo besides the standard protocol. The placebo had the same shape as the Saffron pills. Follow up of DAS28ESR disease activity score was done on the 30th, 45th and 90th day of the study. Results: There was no difference between the intervention and control groups regarding to the DAS28ESR at the end of the study. However, a significant decrease in DAS28-ESR was observed in each group compared to the first visit (p=0. 001). The results also showed no significant difference in the incidence of side effects in both groups. Conclusion: In summary, patients who received pure Saffron pills (100 mg/day) in addition to standard therapy did not have a significant difference in improvement of disease activity from the patients on standard therapy.

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    Cite

    APA: Copy

    SAHEBARI, MARYAM, HEIDARI, HOSSEIN, NABAVI, SHIMA, KHODASHAHI, MANDANA, REZAIEYAZDI, ZAHRA, DADGARMOGHADDAM, MALIHEH, Hosseinzaheh, Hossein, Abbasi, Shaghayegh, & HASHEMZADEH, KAMILA. (2021). A double-blind placebo-controlled randomized trial of oral saffron in the treatment of rheumatoid arthritis. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(4), 332-342. SID. https://sid.ir/paper/687100/en

    Vancouver: Copy

    SAHEBARI MARYAM, HEIDARI HOSSEIN, NABAVI SHIMA, KHODASHAHI MANDANA, REZAIEYAZDI ZAHRA, DADGARMOGHADDAM MALIHEH, Hosseinzaheh Hossein, Abbasi Shaghayegh, HASHEMZADEH KAMILA. A double-blind placebo-controlled randomized trial of oral saffron in the treatment of rheumatoid arthritis. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(4):332-342. Available from: https://sid.ir/paper/687100/en

    IEEE: Copy

    MARYAM SAHEBARI, HOSSEIN HEIDARI, SHIMA NABAVI, MANDANA KHODASHAHI, ZAHRA REZAIEYAZDI, MALIHEH DADGARMOGHADDAM, Hossein Hosseinzaheh, Shaghayegh Abbasi, and KAMILA HASHEMZADEH, “A double-blind placebo-controlled randomized trial of oral saffron in the treatment of rheumatoid arthritis,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 4, pp. 332–342, 2021, [Online]. Available: https://sid.ir/paper/687100/en

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