DISTRIBUTION OF EGFR R521K POLYMORPHISM IN DIFFERENT IRANIAN ETHNIC GROUPS (SHORT COMMUNICATION)

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SHAHROKHSHAHI ASAL; HOUSHMAND MASSOUD

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Journal: Zahedan Journal of Research in Medical Sciences Year:2016 | Volume:18 | Issue:4 Page(s): 0-0

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Information Journal Paper

Title

DISTRIBUTION OF EGFR R521K POLYMORPHISM IN DIFFERENT IRANIAN ETHNIC GROUPS (SHORT COMMUNICATION)

Author(s)

SHAHROKHSHAHI ASAL | HOUSHMAND MASSOUD | Issue Writer Certificate

Keywords

COLORECTAL CANCER

EPIDERMAL GROWTH FACTOR RECEPTOR

R521K POLYMORPHISM

IRANIAN ETHNIC GROUPS

Abstract

Background: The R521K polymorphism of EGFR has attenuated function in ligand binding, tyrosine kinase activation, and growth stimulation.Objectives: We initiated a study to examine R521K polymorphism in six IRANIAN ETHNIC GROUPS.Patients and Methods: This cohort study was designed on 300 Iranian healthy individuals and analyzed by PCR-RFLP protocol.Results: The frequencies of A/A, G/A, G/G genotype were 7.7%, 53.6% and 38.7% respectively.Conclusions: No subject with A/A genotype was detected in Kurds and Lures. The higher frequencies of A/A genotype in Arab and Caspian groups compared to Fars and Turks could be a key determinant of better response to anticancer drugs and favorable prognosis of CRC patients.

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APA: Copy

SHAHROKHSHAHI, ASAL, & HOUSHMAND, MASSOUD. (2016). DISTRIBUTION OF EGFR R₅₂₁K POLYMORPHISM IN DIFFERENT IRANIAN ETHNIC GROUPS (SHORT COMMUNICATION). ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 18(4), 0-0. SID. https://sid.ir/paper/687406/en

Vancouver: Copy

SHAHROKHSHAHI ASAL, HOUSHMAND MASSOUD. DISTRIBUTION OF EGFR R₅₂₁K POLYMORPHISM IN DIFFERENT IRANIAN ETHNIC GROUPS (SHORT COMMUNICATION). ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2016;18(4):0-0. Available from: https://sid.ir/paper/687406/en

IEEE: Copy

ASAL SHAHROKHSHAHI, and MASSOUD HOUSHMAND, “DISTRIBUTION OF EGFR R₅₂₁K POLYMORPHISM IN DIFFERENT IRANIAN ETHNIC GROUPS (SHORT COMMUNICATION),” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 18, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/687406/en

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