ZINC CHLORIDE REVERSE INFLUENCE ON DEXAMETHASONE DEPRESSANT EFFECTS IN ADULT MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAVABI SEYEDEH PARISA; ESHAGH HAROONI HOOMAN; MOAZEDI AHMAD ALI; KHAJEHPOUR LOTFOLAH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Jentashapir Journal of Cellular and Molecular Biology Year:2015 | Volume:6 | Issue:6 Page(s): 1-6

Download Full-Text

View:

347

Download:

151

Cites:

Information Journal Paper

Title

ZINC CHLORIDE REVERSE INFLUENCE ON DEXAMETHASONE DEPRESSANT EFFECTS IN ADULT MALE RATS

Author(s)

NAVABI SEYEDEH PARISA | ESHAGH HAROONI HOOMAN | MOAZEDI AHMAD ALI | KHAJEHPOUR LOTFOLAH | Issue Writer Certificate

Keywords

DEXAMETHASONE

DEPRESSION

GLUCOCORTICOIDS

MALE RAT

ZINC

Abstract

Background: Cumulative evidence shows that dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is involved in the depressive disorders and natural or synthetic GLUCOCORTICOIDS have a direct effect on HPA activity.Objectives: Considering the reports that show ZINC deficiency is one of the causes of depressive-like behavior, the current study aimed to examine the effects of systemic injection of ZINC chloride (ZnCl2) and/or DEXAMETHASONE sodium-phosphate (DEX) on DEPRESSION in adult MALE RATs.Materials and Methods: Different groups received ZnCl2 (2.5, 5, 10, and 20 mg/kg) and DEX (0.5, 1, 5, 10, and 30 mg/kg) and then DEPRESSION was assessed in the forced swimming test (FST).Results: Results showed that DEX 1 significantly increased, while DEX 30 and groups treated with ZINC 10 mg/kg and ZINC 20 mg/kg decreased total immobility time as compared to that of saline group. Also there was a significant decrease of total immobility time when ZINC administered to rats already received DEX 1, compared with that of control group.Conclusions: The current study findings suggest that ZINC has antidepressant effects dose dependently, while administration of DEX induced dual effects on DEPRESSION; therefore, a low dose of DEX showed an increased level of depressive-like behavior while higher doses had antidepressant effects. Also, results showed that ZINC administration could ameliorate depressive-like behavior induced via DEXAMETHASONE in FST.

Cites

No record.

References

No record.

Cite

APA: Copy

NAVABI, SEYEDEH PARISA, ESHAGH HAROONI, HOOMAN, MOAZEDI, AHMAD ALI, & KHAJEHPOUR, LOTFOLAH. (2015). ZINC CHLORIDE REVERSE INFLUENCE ON DEXAMETHASONE DEPRESSANT EFFECTS IN ADULT MALE RATS. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), 6(6), 1-6. SID. https://sid.ir/paper/687427/en

Vancouver: Copy

NAVABI SEYEDEH PARISA, ESHAGH HAROONI HOOMAN, MOAZEDI AHMAD ALI, KHAJEHPOUR LOTFOLAH. ZINC CHLORIDE REVERSE INFLUENCE ON DEXAMETHASONE DEPRESSANT EFFECTS IN ADULT MALE RATS. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH)[Internet]. 2015;6(6):1-6. Available from: https://sid.ir/paper/687427/en

IEEE: Copy

SEYEDEH PARISA NAVABI, HOOMAN ESHAGH HAROONI, AHMAD ALI MOAZEDI, and LOTFOLAH KHAJEHPOUR, “ZINC CHLORIDE REVERSE INFLUENCE ON DEXAMETHASONE DEPRESSANT EFFECTS IN ADULT MALE RATS,” JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), vol. 6, no. 6, pp. 1–6, 2015, [Online]. Available: https://sid.ir/paper/687427/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops