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Information Journal Paper

Title

ANTIBACTERIAL ACTIVITY OF ORIGANUM VULGARE ON STAPHYLOCOCCUS AUREUS IN A RAT MODEL OF SURGICAL WOUND INFECTION

Pages

  19-24

Abstract

 Background: Wound infection is one of the frequent complications in patients with surgical operations. STAPHYLOCOCCUS AUREUS is the most common cause of SURGICAL WOUND infections. ORIGANUM VULGARE, a common culinary herb, has been shown to have strong antimicrobial activity, especially against Gram-positive pathogens.Objective: This study was designed to investigate the antibacterial effects of O. vulgare on S. aureus in SURGICAL WOUNDs using a rat model.Methods: Twenty male Sprague-Dawley rats were divided randomly into two groups of treatment and control rats (1:1). A circular incision was made on the dorsal inter-scapular region of each rat. Then, rats were inoculated topically with 1 × 104 CFU of S. aureus at the site of skin wounds. O. vulgare extract was applied to wounds twice a day during the experiment. Animals of the control group were left untreated.Results: The load of bacteria in untreated rats was 7 × 106 ± 6 CFU/wound while this was 2 × 105 ±1 CFU/wound for the treatment animals, which was significantly lower.Conclusion: Results have showed that topical application of O. vulgare extract on the infected wounds included significant antibacterial activity against S. aureus.

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    APA: Copy

    RAHMANI GOHAR, M., MOSLEMI, H.R., KAFSHDOUZAN, KH., & MAZAHERINEZHAD FARD, R.. (2016). ANTIBACTERIAL ACTIVITY OF ORIGANUM VULGARE ON STAPHYLOCOCCUS AUREUS IN A RAT MODEL OF SURGICAL WOUND INFECTION. JOURNAL OF MEDICINAL PLANTS, 15(57), 19-24. SID. https://sid.ir/paper/688336/en

    Vancouver: Copy

    RAHMANI GOHAR M., MOSLEMI H.R., KAFSHDOUZAN KH., MAZAHERINEZHAD FARD R.. ANTIBACTERIAL ACTIVITY OF ORIGANUM VULGARE ON STAPHYLOCOCCUS AUREUS IN A RAT MODEL OF SURGICAL WOUND INFECTION. JOURNAL OF MEDICINAL PLANTS[Internet]. 2016;15(57):19-24. Available from: https://sid.ir/paper/688336/en

    IEEE: Copy

    M. RAHMANI GOHAR, H.R. MOSLEMI, KH. KAFSHDOUZAN, and R. MAZAHERINEZHAD FARD, “ANTIBACTERIAL ACTIVITY OF ORIGANUM VULGARE ON STAPHYLOCOCCUS AUREUS IN A RAT MODEL OF SURGICAL WOUND INFECTION,” JOURNAL OF MEDICINAL PLANTS, vol. 15, no. 57, pp. 19–24, 2016, [Online]. Available: https://sid.ir/paper/688336/en

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