مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PROPYLTHIOURACIL-INDUCED MITOCHONDRIAL DYSFUNCTION IN LIVER AND ITS RELEVANCE TO DRUG-INDUCED HEPATOTOXICITY

Pages

  95-102

Abstract

 Background: Propylthiouracil (PTU) administration is associated with several cases of hepatotoxicity, especially in children. The mechanism (s) of PTU-induced hepatotoxicity is obscure. In the current study, we aimed to assess the effect of PTU on hepatocytes mitochondria in different experimental models.Methods: Mice were treated with PTU (10, 20, 40, 80, and 100 mg/kg, i.p) then, the liver mitochondria were isolated and evaluated. Moreover, liver mitochondria were isolated from normal mice and incubated with increasing concentrations of PTU (10 mM-1 mM). Mitochondrial dehydrogenases activity, mitochondrial membrane potential, mitochondrial swelling, and mitochondrial adenosine triphosphate (ATP) content were monitored.Results: PTU hepatotoxicity was biochemically evident in mice by increased serum biomarkers of liver injury. PTU also caused a decrease in mitochondrial dehydrogenases activity, increased mitochondrial swelling, depleted mitochondrial ATP, and caused mitochondrial depolarization both in vitro and in vivo.Conclusion: Our data suggest MITOCHONDRIAL DYSFUNCTION as a mechanism for PTU-induced hepatotoxicity.

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    Cite

    APA: Copy

    JAMSHIDZADEH, AKRAM, NIKNAHAD, HOSSEIN, HEIDARI, REZA, AZADBAKHT, MARYAM, KHODAEI, FOROUZAN, ARABNEZHAD, MOHAMMAD REZA, & FARSHAD, OMID. (2017). PROPYLTHIOURACIL-INDUCED MITOCHONDRIAL DYSFUNCTION IN LIVER AND ITS RELEVANCE TO DRUG-INDUCED HEPATOTOXICITY. PHARMACEUTICAL SCIENCES, 23(2), 95-102. SID. https://sid.ir/paper/688669/en

    Vancouver: Copy

    JAMSHIDZADEH AKRAM, NIKNAHAD HOSSEIN, HEIDARI REZA, AZADBAKHT MARYAM, KHODAEI FOROUZAN, ARABNEZHAD MOHAMMAD REZA, FARSHAD OMID. PROPYLTHIOURACIL-INDUCED MITOCHONDRIAL DYSFUNCTION IN LIVER AND ITS RELEVANCE TO DRUG-INDUCED HEPATOTOXICITY. PHARMACEUTICAL SCIENCES[Internet]. 2017;23(2):95-102. Available from: https://sid.ir/paper/688669/en

    IEEE: Copy

    AKRAM JAMSHIDZADEH, HOSSEIN NIKNAHAD, REZA HEIDARI, MARYAM AZADBAKHT, FOROUZAN KHODAEI, MOHAMMAD REZA ARABNEZHAD, and OMID FARSHAD, “PROPYLTHIOURACIL-INDUCED MITOCHONDRIAL DYSFUNCTION IN LIVER AND ITS RELEVANCE TO DRUG-INDUCED HEPATOTOXICITY,” PHARMACEUTICAL SCIENCES, vol. 23, no. 2, pp. 95–102, 2017, [Online]. Available: https://sid.ir/paper/688669/en

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