THE EFFECT OF VITAMIN D SUPPLEMENTATION ON GESTATIONAL DIABETES IN HIGH-RISK WOMEN: RESULTS FROM A RANDOMIZED PLACEBO-CONTROLLED TRIAL

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SHAHGHEIBI SHOLEH; FARHADIFAR FARIBA; POUYA BAHAR

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2016 | Volume:21 | Issue:1 Page(s): 0-0

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Title

THE EFFECT OF VITAMIN D SUPPLEMENTATION ON GESTATIONAL DIABETES IN HIGH-RISK WOMEN: RESULTS FROM A RANDOMIZED PLACEBO-CONTROLLED TRIAL

Author(s)

SHAHGHEIBI SHOLEH | FARHADIFAR FARIBA | POUYA BAHAR | Issue Writer Certificate

Keywords

DIABETES

FIRST TRIMESTER

GESTATIONAL DIABETES

PREGNANCY

SANANDAJ

VITAMIN D

Abstract

Background: VITAMIN D deficiency is common in PREGNANCY, leading to increase in the frequency of preeclampsia, cesarean delivery, neonatal bacterial vaginosis, and gestational DIABETES. The current study was designed and implemented to investigate the effect ofvitamin D during the first and second trimesters of PREGNANCY in reducing the risk of gestational DIABETES mellitus (GDM) in womenwho are at high risk [history of GDM, birth macrosomia, family history, and high body mass index (BMI)]. Materials and Methods: In a randomized, double-blind, and placebo-controlled trial, 90 pregnant women who had at least one risk factor for GDM wererandomized into intervention (46 participants) and control (44 participants) groups. Participants in the intervention group took5000 units of VITAMIN D daily and the control group took placebo until the 26th week of PREGNANCY. Then the glucose challenge test(GCT) and the glucose tolerance test (GTT) were performed to evaluate GDM.Results: Mean ± standard deviation (SD) age was31.28 ± 6.38 years and 29 ± 6.24 years for the intervention group and the placebo group, respectively, (P>0.05). In addition, therewere no significant differences between two groups in terms of VITAMIN D levels and GCT (P>0.05), and the difference was notsignificant. The incidence of DIABETES in the intervention groups was statistically lower than in control group (11.4% vs 34.8; P<0.01). The results showed that abnormal GCT in the placebo group was statistically higher than in intervention group (35.9% vs 10.9P<0.005).Conclusion: The results of the current study showed that the prescription of VITAMIN D supplementation in the first andsecond trimesters of PREGNANCY was effective in reducing GDM and controlling GTT and GTC.

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APA: Copy

SHAHGHEIBI, SHOLEH, FARHADIFAR, FARIBA, & POUYA, BAHAR. (2016). THE EFFECT OF VITAMIN D SUPPLEMENTATION ON GESTATIONAL DIABETES IN HIGH-RISK WOMEN: RESULTS FROM A RANDOMIZED PLACEBO-CONTROLLED TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(1), 0-0. SID. https://sid.ir/paper/688695/en

Vancouver: Copy

SHAHGHEIBI SHOLEH, FARHADIFAR FARIBA, POUYA BAHAR. THE EFFECT OF VITAMIN D SUPPLEMENTATION ON GESTATIONAL DIABETES IN HIGH-RISK WOMEN: RESULTS FROM A RANDOMIZED PLACEBO-CONTROLLED TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(1):0-0. Available from: https://sid.ir/paper/688695/en

IEEE: Copy

SHOLEH SHAHGHEIBI, FARIBA FARHADIFAR, and BAHAR POUYA, “THE EFFECT OF VITAMIN D SUPPLEMENTATION ON GESTATIONAL DIABETES IN HIGH-RISK WOMEN: RESULTS FROM A RANDOMIZED PLACEBO-CONTROLLED TRIAL,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/688695/en

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