DIAGNOSTIC VALUE OF ALARM SYMPTOMS FOR UPPER GI MALIGNANCY IN PATIENTS REFERRED TO GI CLINIC: A 7 YEARS CROSS SECTIONAL STUDY

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EMAMI MOHAMMAD HASAN; ATAEI KHORASGANI MASOUD; JAFARI POZVEH NASIM

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Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2017 | Volume:22 | Issue:6 Page(s): 0-0

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Title

DIAGNOSTIC VALUE OF ALARM SYMPTOMS FOR UPPER GI MALIGNANCY IN PATIENTS REFERRED TO GI CLINIC: A 7 YEARS CROSS SECTIONAL STUDY

Author(s)

EMAMI MOHAMMAD HASAN | ATAEI KHORASGANI MASOUD | JAFARI POZVEH NASIM | Issue Writer Certificate

Keywords

ALARM SYMPTOM

DIAGNOSTIC ACCURACY

UPPER GASTROINTESTINAL MALIGNANCY

Abstract

Background: Early upper gastrointestinal (UGI) cancer detection had led to organ-preserving endoscopic therapy. Endoscopy is a suitable method of early diagnosis of UGI malignancies. In Iran, exclusion of malignancy is the most important indication for endoscopy. This study is designed to see whether using ALARM SYMPTOMs can predict the risk of cancer in patients. Materials and Methods: A total of 3414 patients referred to a tertiary gastrointestinal (GI) clinic in Isfahan, Iran, from 2009 to 2016 with dyspepsia, gastroesophageal reflux disease (GERD), and ALARM SYMPTOMs, such as weight loss, dysphagia, GI bleeding, vomiting, positive familial history for cancer, and anorexia. Each patient had been underwent UGI endoscopy and patient data, including histology results, had been collected in the computer. We used logistic regression models to estimate the DIAGNOSTIC ACCURACY of each ALARM SYMPTOMs.Results: A total of 3414 patients with ALARM SYMPTOMs entered in this study, of whom 72 (2.1%) had an UGI malignancy. According to the logistic regression model, dysphagia (P<0.001) and weight loss (P<0.001) were found to be significant positive predictive factors for malignancy. Furthermore, males were in a significantly higher risk of developing UGI malignancy. Through receiver operating characteristic curve and the area under the curve (AUC) with adequate overall calibration and model fit measures, dysphagia and weight loss as a related cancer predictor had a high DIAGNOSTIC ACCURACY (accuracy=0.72, AUC=0.881). Using a combination of age, ALARM SYMPTOMs will lead to high positive predictive value for cancer.Conclusion: We recommend to do an early endoscopy for any patient with UGI symptoms and to take multiple biopsies from any rudeness or suspicious lesion, especially for male gender older than 50, dysphagia, or weight loss.

Cites

Cancer trends in a province of Southwest of Iran, 2003– 2016

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APA: Copy

EMAMI, MOHAMMAD HASAN, ATAEI KHORASGANI, MASOUD, & JAFARI POZVEH, NASIM. (2017). DIAGNOSTIC VALUE OF ALARM SYMPTOMS FOR UPPER GI MALIGNANCY IN PATIENTS REFERRED TO GI CLINIC: A 7 YEARS CROSS SECTIONAL STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 22(6), 0-0. SID. https://sid.ir/paper/688716/en

Vancouver: Copy

EMAMI MOHAMMAD HASAN, ATAEI KHORASGANI MASOUD, JAFARI POZVEH NASIM. DIAGNOSTIC VALUE OF ALARM SYMPTOMS FOR UPPER GI MALIGNANCY IN PATIENTS REFERRED TO GI CLINIC: A 7 YEARS CROSS SECTIONAL STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2017;22(6):0-0. Available from: https://sid.ir/paper/688716/en

IEEE: Copy

MOHAMMAD HASAN EMAMI, MASOUD ATAEI KHORASGANI, and NASIM JAFARI POZVEH, “DIAGNOSTIC VALUE OF ALARM SYMPTOMS FOR UPPER GI MALIGNANCY IN PATIENTS REFERRED TO GI CLINIC: A 7 YEARS CROSS SECTIONAL STUDY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 22, no. 6, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/688716/en

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