مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE INTERFERON LAMBDA 4 RS368234815 PREDICTS TREATMENT RESPONSE TO PEGYLATED‑INTERFERON ALPHA AND RIBAVIRIN IN HEMOPHILIC PATIENTS WITH CHRONIC HEPATITIS C

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Abstract

 Background: A dinucleotide variant rs368234815 in interferon lambda 4 (IFNL4) gene was recently found to be associated with the HEPATITIS C virus (HCV) treatment response. This study aimed to assess the impact of IFNL4 rs368234815 polymorphism on treatment response to pegylated-IFN alpha (Peg-IFN-a) and ribavirin (RBV) in hemophilic patients with chronic HEPATITIS C (CHC). Materials and Methods: In this retrospective study, 92 hemophilic patients with CHC who were treated with Peg-IFN-a/RBV were investigated. Single-nucleotide polymorphisms (SNPs) in IFNL genomic region including rs368234815, rs12979860, and rs8099917 were analyzed by DNA sequencing.Results: Of the 92 patients, 63 (68.5%) achieved sustained virological response (SVR). Of the 43 patients with rs368234815 TT/TT genotype, 36 (83.7%) achieved SVR, while in 49 patients with non-TT/TT genotypes, 27 (55.1%) achieved SVR. Other pretreatment parameters predicted SVR were patients body mass index, HCV genotype, rs12979860, and rs8099917 SNPs. In multivariate analysis, all above-mentioned parameters except rs8099917 remained as predictors of SVR. IFNL4 rs368234815 was a strong predictor of SVR; however, the prediction power of this SNP was the same as that of rs12979860 SNP in the patients of the current study.Conclusion: IFNL4 rs368234815 SNP can be considered for decision-making in the treatment of HCV-infected patients.

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    APA: Copy

    KESHVARI, MARYAM, ALAVIAN, SEYED MOAYED, BEHNAVA, BITA, POURYASIN, ALI, & SHARAFI, HEIDAR. (2016). THE INTERFERON LAMBDA 4 RS368234815 PREDICTS TREATMENT RESPONSE TO PEGYLATED?INTERFERON ALPHA AND RIBAVIRIN IN HEMOPHILIC PATIENTS WITH CHRONIC HEPATITIS C. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(5), 0-0. SID. https://sid.ir/paper/688728/en

    Vancouver: Copy

    KESHVARI MARYAM, ALAVIAN SEYED MOAYED, BEHNAVA BITA, POURYASIN ALI, SHARAFI HEIDAR. THE INTERFERON LAMBDA 4 RS368234815 PREDICTS TREATMENT RESPONSE TO PEGYLATED?INTERFERON ALPHA AND RIBAVIRIN IN HEMOPHILIC PATIENTS WITH CHRONIC HEPATITIS C. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(5):0-0. Available from: https://sid.ir/paper/688728/en

    IEEE: Copy

    MARYAM KESHVARI, SEYED MOAYED ALAVIAN, BITA BEHNAVA, ALI POURYASIN, and HEIDAR SHARAFI, “THE INTERFERON LAMBDA 4 RS368234815 PREDICTS TREATMENT RESPONSE TO PEGYLATED?INTERFERON ALPHA AND RIBAVIRIN IN HEMOPHILIC PATIENTS WITH CHRONIC HEPATITIS C,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 5, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/688728/en

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