ASSOCIATION OF RETINOL‑BINDING PROTEIN 4 WITH METABOLIC SYNDROME IN FIRST‑DEGREE RELATIVES OF TYPE 2 DIABETIC PATIENTS

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TABESH MARJAN; Noroozi Atsa; AMINI MASOOD; FEIZI AWAT; SARAF BANK SAHAR; ZARE MARYAM

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2016 | Volume:21 | Issue:11 Page(s): 0-0

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Title

ASSOCIATION OF RETINOL‑BINDING PROTEIN 4 WITH METABOLIC SYNDROME IN FIRST‑DEGREE RELATIVES OF TYPE 2 DIABETIC PATIENTS

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Keywords

FIRST‑DEGREE RELATIONS OF TYPE 2 DIABETIC PATIENTS

METABOLIC SYNDROME

RETINOL BINDING PROTEIN 4

Abstract

Background: Retinol-binding protein 4 (RBP4) is known to regulate lipid and glucose metabolism and insulin resistance. The influences of RBP4 on METABOLIC SYNDROME (MS) are still unclear. The purpose of this study is to evaluate the association between serum levels of RBP4 and MS components in first-degree relations of type 2 diabetic patients. Materials and Methods: This cross-sectional study was performed within the framework of the diabetes prevention project in Isfahan. This study has been conducted during 2012–2013. Seventy-eight subjects participate, with an average age of 43.20 ± 5.29 years. Weight, height, waist and hip circumferences, blood pressure (BP) of participants, fasting plasma glucose, hemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol, triglyceride (TG), and serum RBP4 were measured from fasting blood sample taken from each participant after an overnight fast (12–14 h).Results: Systolic and diastolic BP were significantly higher in people in top median of RBP4 (11.8 ± 1.5 vs.11.0 ± 1.2, P=0.01 and 7.8 ± 1.0 vs.7.3 ± 0.9, P=0.03). Moreover, TG in people with high levels of RBP4 was higher compared with those with low levels of RBP4 (177.7 ± 97.6 vs.138.7 ± 56.9, P=0.02). People with low levels of RBP4 had significant greater hip circumferences (107.9 ± 7.5 vs.104.3 ± 8.0, P=0.04). There was no correlation between RBP4 and MS in crude model (odds ratio [OR]: 1.00, 0.95–1.05, P=0.97). This null correlation remained after adjustment for body mass index, age, and physical activity (OR: 0.93, 0.91–1.07, P=0.31).Conclusion: Although RBP4 levels were positively association with some risk factors of MS including hip circumference, TG, and systolic and diastolic BP, it does not seem to be a valuable marker for identification of the MS in the first relative degree of diabetic patients.

Cites

Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta‑ analysis of case– control studies

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APA: Copy

TABESH, MARJAN, Noroozi, Atsa, AMINI, MASOOD, FEIZI, AWAT, SARAF BANK, SAHAR, & ZARE, MARYAM. (2016). ASSOCIATION OF RETINOL?BINDING PROTEIN 4 WITH METABOLIC SYNDROME IN FIRST?DEGREE RELATIVES OF TYPE 2 DIABETIC PATIENTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(11), 0-0. SID. https://sid.ir/paper/688773/en

Vancouver: Copy

TABESH MARJAN, Noroozi Atsa, AMINI MASOOD, FEIZI AWAT, SARAF BANK SAHAR, ZARE MARYAM. ASSOCIATION OF RETINOL?BINDING PROTEIN 4 WITH METABOLIC SYNDROME IN FIRST?DEGREE RELATIVES OF TYPE 2 DIABETIC PATIENTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(11):0-0. Available from: https://sid.ir/paper/688773/en

IEEE: Copy

MARJAN TABESH, Atsa Noroozi, MASOOD AMINI, AWAT FEIZI, SAHAR SARAF BANK, and MARYAM ZARE, “ASSOCIATION OF RETINOL?BINDING PROTEIN 4 WITH METABOLIC SYNDROME IN FIRST?DEGREE RELATIVES OF TYPE 2 DIABETIC PATIENTS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 11, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/688773/en

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