ANTIGENIC AND IMMUNOGENIC EVALUATION OF HELICOBACTER PYLORI FLAA EPITOPES

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ZAREI MANSOOR; MOSAYEBI GHASEM; KHANSARINEJAD BEHZAD; ABTAHI HAMID

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:8 Page(s): 920-926

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Title

ANTIGENIC AND IMMUNOGENIC EVALUATION OF HELICOBACTER PYLORI FLAA EPITOPES

Author(s)

ZAREI MANSOOR | MOSAYEBI GHASEM | KHANSARINEJAD BEHZAD | ABTAHI HAMID | Issue Writer Certificate

Keywords

FLAGELLA

HELICOBACTER PYLORI

IMMUNOGENICITY

VACCINE

Abstract

Objective(s): HELICOBACTER PYLORI are among most common human pathogens affecting at least half of the world’s population. Mobility is one of the important primary factors in bacterial colonization and invasion. The purpose of this research is cloning, expression, and purification of FlaA protein specific epitopes in order to evaluate their antigenicity and IMMUNOGENICITY.Materials and Methods: The antigenic region of the flaA gene was bioinformatically predicted using Epitope mapping software’s and the predicted epitopes were expressed in a prokaryotic expression vector. The antigen was injected into the animal model (mice BALB/c) and some indicators including IgG1, IgG2a, IgA, IFN-g, and IL 5 were measured.Results: The IMMUNOGENICITY studies in animal models by measuring serum antibodies (IgG1, IgG2a, and IgA) and cytokines (IFN-g and IL5) revealed that the rFlaA induces a proper immune response in animal models.Conclusion: The recombinant FlaA protein is antigenic and immunogenic. Therefore, it might be used in order to design of specific diagnostic kits and recombinant VACCINEs against H. pylori.

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APA: Copy

ZAREI, MANSOOR, MOSAYEBI, GHASEM, KHANSARINEJAD, BEHZAD, & ABTAHI, HAMID. (2017). ANTIGENIC AND IMMUNOGENIC EVALUATION OF HELICOBACTER PYLORI FLAA EPITOPES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(8), 920-926. SID. https://sid.ir/paper/688860/en

Vancouver: Copy

ZAREI MANSOOR, MOSAYEBI GHASEM, KHANSARINEJAD BEHZAD, ABTAHI HAMID. ANTIGENIC AND IMMUNOGENIC EVALUATION OF HELICOBACTER PYLORI FLAA EPITOPES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(8):920-926. Available from: https://sid.ir/paper/688860/en

IEEE: Copy

MANSOOR ZAREI, GHASEM MOSAYEBI, BEHZAD KHANSARINEJAD, and HAMID ABTAHI, “ANTIGENIC AND IMMUNOGENIC EVALUATION OF HELICOBACTER PYLORI FLAA EPITOPES,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 8, pp. 920–926, 2017, [Online]. Available: https://sid.ir/paper/688860/en

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