COMPARISON OF THE EFFICACY OF HEPATITIS B VACCINATION BY DIFFERENT ROUTES OF IMMUNIZATION

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BIJANI B.; CHARKHCHIAN M.; ASEFZADEH M.; ASEFZADEH S.; MAHRAM M.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2012 | Volume:15 | Issue:1 (60) Page(s): 18-26

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Title

COMPARISON OF THE EFFICACY OF HEPATITIS B VACCINATION BY DIFFERENT ROUTES OF IMMUNIZATION

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Keywords

ACTIVE IMMUNIZATIONQ2

HEPATITIS BQ2

RENAL FAILUREQ2

Abstract

Background: Low immunogenicity of HEPATITIS B vaccine is an important problem in patients with chronic RENAL FAILURE (CRF). A possible solution is intradermal versus conventional intramuscular delivery of vaccine in this population. The goal of this study was to compare the efficacy of these routes of vaccination in Bu-alicina Dialysis Center, Qazvin, Iran.Materials and Methods: This randomized clinical trial was done on 29 CRF non-responders randomly allocated to two groups. Fifteen patients received 40 μg of euvax B vaccine intradermally and 14 patients received 160 μg of this vaccine intramuscularly. Anti-HBs antibody titre was measured after 1, 6, and 12 months. Seroprotection was defined as anti-HBs antibody titre above 10 lU/L. Data were analyzed using SPSS software version 16.Results: Difference of seroprotection rate between two groups was not statistically significant after1and 6 months; however, after 12 months, seroprotection rate was 93.3% in the interadermal group versus 50% in the intramuscular group (p<0.05).Conclusion: Considering the high cost of vaccination, intradermal vaccination may be a reasonable choice in CRF patients.

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APA: Copy

BIJANI, B., CHARKHCHIAN, M., ASEFZADEH, M., ASEFZADEH, S., & MAHRAM, M.. (2012). COMPARISON OF THE EFFICACY OF HEPATITIS B VACCINATION BY DIFFERENT ROUTES OF IMMUNIZATION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 15(1 (60)), 18-26. SID. https://sid.ir/paper/68947/en

Vancouver: Copy

BIJANI B., CHARKHCHIAN M., ASEFZADEH M., ASEFZADEH S., MAHRAM M.. COMPARISON OF THE EFFICACY OF HEPATITIS B VACCINATION BY DIFFERENT ROUTES OF IMMUNIZATION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2012;15(1 (60)):18-26. Available from: https://sid.ir/paper/68947/en

IEEE: Copy

B. BIJANI, M. CHARKHCHIAN, M. ASEFZADEH, S. ASEFZADEH, and M. MAHRAM, “COMPARISON OF THE EFFICACY OF HEPATITIS B VACCINATION BY DIFFERENT ROUTES OF IMMUNIZATION,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 15, no. 1 (60), pp. 18–26, 2012, [Online]. Available: https://sid.ir/paper/68947/en

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