THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN 15 AND 17 AND SEVERITY OF ACUTE PANCREATITIS

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FATEH SH.; MAMAGHANI M.R.; MOSAYEBI GH.

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2012 | Volume:15 | Issue:1 (60) Page(s): 70-76

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Title

THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN 15 AND 17 AND SEVERITY OF ACUTE PANCREATITIS

Author(s)

FATEH SH. | MAMAGHANI M.R. | MOSAYEBI GH. | Issue Writer Certificate

Keywords

IL-15Q2

IL-17Q2

SEVERITY OF ACUTE PANCREATITISQ2

Abstract

Background: Because of high mortality and morbidity of severe acute pancreatitis (AP) and its increasing incidence in recent years, early detection of severity of AP is very important. Since interleukin (IL) rapidly responds to body temperature changes, this study was done to examine the relationship between blood levels of interleukin 15 and 17 and SEVERITY OF ACUTE PANCREATITIS.Materials and Methods: In this cross-sectional study, 52 patients with AP were studied. For all patients, paraclinical information, Ranson criteria, and APACHE-II were completed. Serum interleukin 15 and 17 levels were measured by ELISA method. Then the relationship between them and AP severity was determined based on Ranson criteria and APACHE-II.Results: In this study, 36.5% of the patients were male and 63.5% were female and the mean age was 61.06 years. The serum level of IL-17 was negatively correlated with the severity of AP based on Ranson criteria (p=0.021, r=-0.319). ROC curve showed significant values for blood level of IL-15 and CRP in AP diagnosis. Sensitivities were 92.3% and 78.8% and specificities were 40% and 48%, respectively.Conclusion: Based on Ranson criteria, the role of serum level of IL-17 as an unknown factor was seen significant in determining the severity of AP. However, the diagnostic value of serum IL-15 should also be verified with further studies.

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APA: Copy

FATEH, SH., MAMAGHANI, M.R., & MOSAYEBI, GH.. (2012). THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN 15 AND 17 AND SEVERITY OF ACUTE PANCREATITIS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 15(1 (60)), 70-76. SID. https://sid.ir/paper/68950/en

Vancouver: Copy

FATEH SH., MAMAGHANI M.R., MOSAYEBI GH.. THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN 15 AND 17 AND SEVERITY OF ACUTE PANCREATITIS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2012;15(1 (60)):70-76. Available from: https://sid.ir/paper/68950/en

IEEE: Copy

SH. FATEH, M.R. MAMAGHANI, and GH. MOSAYEBI, “THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN 15 AND 17 AND SEVERITY OF ACUTE PANCREATITIS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 15, no. 1 (60), pp. 70–76, 2012, [Online]. Available: https://sid.ir/paper/68950/en

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