COMPARISON OF THE EFFECTSOF HIGH DOSEAND LOW (COMMON) DOSE OF ALFENTANYL ON HEMODYNAMI CCHANGES INDUCED BY LARYNGOSCOPY AND TRACHEAL INTUBATION

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KHALILI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Arak University Medical Sciences Year:2003 | Volume:5 | Issue:4 (25) Page(s): 36-40

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Title

COMPARISON OF THE EFFECTSOF HIGH DOSEAND LOW (COMMON) DOSE OF ALFENTANYL ON HEMODYNAMI CCHANGES INDUCED BY LARYNGOSCOPY AND TRACHEAL INTUBATION

Author(s)

KHALILI M. | Issue Writer Certificate

Keywords

PRESSOR RESPONSEQ4

LARYNGOSCOPYQ4

ALFENTANYLQ3

HEMODYNAMICQ3

Abstract

Introduction: Sympathetic stimulation and PRESSOR RESPONSEs including tachycardia, hypertension and tachyarrhytmias caused by LARYNGOSCOPY and tracheal intubations may result in severe complications in susceptible patients. Opioid anesthetics are one of the several drugs used to attenuate this response but prolonged postoperative respiratory depression is the major complication distracting from their high dose administration which is needed for complete amelioration of PRESSOR RESPONSE. In this study ALFENTANYL, as a rapid acting and short duration opioid (without prolonged respiratory depression), was used in two different dosages for controlling of PRESSOR RESPONSE. Materials and Methods: In a single blind, controlled clinical trial, 236 patients (in the range of 18 to 70 years old), whom needing LARYNGOSCOPY and tracheal intubations were selected and randomly divided into two equal groups. First group received low (current) dose (15µgr/kg) ALFENTANYL, and the 9ther received high dose (45µgr/kg), prior to LARYNGOSCOPY and tracheal intubations. Type and dosage of induction drugs were the same and matched in both groups. Blood pressure and heart rate were measured before intravenous induction and after intubations of the tracheal in all patients. Mercurial sphygmomanometer and pulse oximeter were used for these measurements. Incidence of such complications as hypotention, muscle stiffness and neurologic hyper reactivity, were also measured. Data were analysed by Z distribution and Chi square tests. Results: ALFENTANYL was effective in controlling PRESSOR RESPONSE in both groups. In the case of heart rate, the mean difference between two groups was not significant. There was a significant difference mean arterial pressure between two groups (p < 0.05). In high dose group, incidence of complications was higher for severe hypotension (p < 0.05), stiff chest syndrome (p < 0.05), and neurologic hyperreactivity (p < 0.05). Conclusion: Hign dose of ALFENTANYL is more efficient in controlling of PRESSOR RESPONSE than low dose of the drug. High dose administration also may results in some complications. In this study current dose of ALFENTANYL is recommended for controlling of PRESSOR RESPONSE, but high dose may be used with some modification in the dose of induction agents.

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APA: Copy

KHALILI, M.. (2003). COMPARISON OF THE EFFECTSOF HIGH DOSEAND LOW (COMMON) DOSE OF ALFENTANYL ON HEMODYNAMI CCHANGES INDUCED BY LARYNGOSCOPY AND TRACHEAL INTUBATION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 5(4 (25)), 36-40. SID. https://sid.ir/paper/68971/en

Vancouver: Copy

KHALILI M.. COMPARISON OF THE EFFECTSOF HIGH DOSEAND LOW (COMMON) DOSE OF ALFENTANYL ON HEMODYNAMI CCHANGES INDUCED BY LARYNGOSCOPY AND TRACHEAL INTUBATION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2003;5(4 (25)):36-40. Available from: https://sid.ir/paper/68971/en

IEEE: Copy

M. KHALILI, “COMPARISON OF THE EFFECTSOF HIGH DOSEAND LOW (COMMON) DOSE OF ALFENTANYL ON HEMODYNAMI CCHANGES INDUCED BY LARYNGOSCOPY AND TRACHEAL INTUBATION,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 5, no. 4 (25), pp. 36–40, 2003, [Online]. Available: https://sid.ir/paper/68971/en

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