Human Cytomegalovirus and Human Herpesvirus-6 and Wilms Tumor: Is There a Link?

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KAZEMI AGHDAM MARYAM; NADJI SEYED ALIREZA; KHODDAMI MALIHEH; Tehrani Mohamad Mahdi

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Journal Paper

Paper Information

Journal: Archives of Pediatric Infectious Diseases Year:2021 | Volume:9 | Issue:1 Page(s): 0-0

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Title

Human Cytomegalovirus and Human Herpesvirus-6 and Wilms Tumor: Is There a Link?

Author(s)

KAZEMI AGHDAM MARYAM | NADJI SEYED ALIREZA | KHODDAMI MALIHEH | Tehrani Mohamad Mahdi | Issue Writer Certificate

Keywords

Human Cytomegalovirus

Human Herpes Virus-6

Polymerase Chain Reaction

Wilms Tumor

Abstract

Background: Identifying etiologic factors contributing to Wilms Tumor (WT) is necessary for its prevention and treatment. Oncogenic viruses cause nearly 20% of all human cancers. Although trials on preventing virus-caused cancers are complex and diﬃ cult, but they are not impossible to conduct. Human Cytomegalovirus (HCMV) and Human Herpes Virus-6 (HHV6) can cause diﬀ erent types of cancers. Objectives: The current study aimed to investigate whether HCMV and HHV6-DNA are present in patients with WT. This is the ﬁ rst study of this kind in Iran. Methods: This study was performed on patients with kidney disorders who were referring to Moﬁ d Pediatrics Hospital, Tehran (Iran), during 2010-16. In total, 98 kidney samples (49 patients with WT and 49 normal kidneys (autopsy) and kidneys with benign noninfectious lesions) were investigated to identify HCMV and HHV6-DNA. Qualitative Polymerase Chain Reaction (PCR) method and nested Polymerase Chain Reaction (nested-PCR) technique were used to identify HCMV and HHV6, respectively. Results: No signiﬁ cant diﬀ erence was found between WT patients and controls concerning the HCMV or HHV6. Conclusions: Based on the ﬁ ndings, it can be concluded that there is no association between these viruses and WT.

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APA: Copy

KAZEMI AGHDAM, MARYAM, NADJI, SEYED ALIREZA, KHODDAMI, MALIHEH, & Tehrani, Mohamad Mahdi. (2021). Human Cytomegalovirus and Human Herpesvirus-6 and Wilms Tumor: Is There a Link?. ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, 9(1), 0-0. SID. https://sid.ir/paper/690004/en

Vancouver: Copy

KAZEMI AGHDAM MARYAM, NADJI SEYED ALIREZA, KHODDAMI MALIHEH, Tehrani Mohamad Mahdi. Human Cytomegalovirus and Human Herpesvirus-6 and Wilms Tumor: Is There a Link?. ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/690004/en

IEEE: Copy

MARYAM KAZEMI AGHDAM, SEYED ALIREZA NADJI, MALIHEH KHODDAMI, and Mohamad Mahdi Tehrani, “Human Cytomegalovirus and Human Herpesvirus-6 and Wilms Tumor: Is There a Link?,” ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/690004/en

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