Nonsyndromic Primary Diffuse Leptomeningeal Melanomatosis in a Child

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TAVANA RAD Salim; ASHRAFZADEH FARAH; GOLMAKANI Hassan; GANJEIFAR BABAK

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Journal Paper

Paper Information

Journal: Iranian Journal of Child Neurology Year:2021 | Volume:15 | Issue:3 Page(s): 153-157

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Title

Nonsyndromic Primary Diffuse Leptomeningeal Melanomatosis in a Child

Author(s)

TAVANA RAD Salim | ASHRAFZADEH FARAH | GOLMAKANI Hassan | GANJEIFAR BABAK | Issue Writer Certificate

Keywords

Spine

Central nervous system

Melanoma

Child

Abstract

In this study, we present a case of primary diffuse leptomeningeal Melanomatosis (PDLM), without neurocutaneous melanosis syndrome. A female patient (age: 14 years) presented with headache, nausea, vomiting, vertigo, diplopia, and lower limb weakness. The magnetic resonance imaging (MRI) showed leptomeningeal isointensity on T1-and T2-weighted images and hyperintensity on fluid attenuation inversion recovery (FLAIR) sequences. Definitive histological examination showed a densely cellular tumor, characterized by irregular clusters of large pleomorphic cells and melanin in tumor cells. Adjuvant therapy was refused by the parents, and the patient died within six months. Primary diffuse leptomeningeal Melanomatosis is recognized as an uncommon and malignant Melanoma affecting the Central nervous system. In case comorbidities are not diagnosed in patients with unusual symptoms of meningitis, diagnostic methods such as cerebrospinal fluid analysis and Central nervous system biopsy can be helpful in identifying other underlying conditions.

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APA: Copy

TAVANA RAD, Salim, ASHRAFZADEH, FARAH, GOLMAKANI, Hassan, & GANJEIFAR, BABAK. (2021). Nonsyndromic Primary Diffuse Leptomeningeal Melanomatosis in a Child. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 15(3), 153-157. SID. https://sid.ir/paper/690125/en

Vancouver: Copy

TAVANA RAD Salim, ASHRAFZADEH FARAH, GOLMAKANI Hassan, GANJEIFAR BABAK. Nonsyndromic Primary Diffuse Leptomeningeal Melanomatosis in a Child. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2021;15(3):153-157. Available from: https://sid.ir/paper/690125/en

IEEE: Copy

Salim TAVANA RAD, FARAH ASHRAFZADEH, Hassan GOLMAKANI, and BABAK GANJEIFAR, “Nonsyndromic Primary Diffuse Leptomeningeal Melanomatosis in a Child,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 15, no. 3, pp. 153–157, 2021, [Online]. Available: https://sid.ir/paper/690125/en

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