Comparing Benzodiazepines-morphine-induced Respiratory Depression by Analyzing Respiratory Pattern in Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ALIMORADIAN ABBAS; Pazhoohan Saeed; Mirzabeygi Omid; Naderinia Kiana

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2021 | Volume:23 | Issue:6 (148) Page(s): 850-852

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Comparing Benzodiazepines-morphine-induced Respiratory Depression by Analyzing Respiratory Pattern in Rats

Author(s)

ALIMORADIAN ABBAS | Pazhoohan Saeed | Mirzabeygi Omid | Naderinia Kiana | Issue Writer Certificate

Keywords

Morphine

Benzodiazepines

Breathing

Abstract

Background and Aim Opioid and benzodiazepine family drugs are concurrently used in various patients. Considering the respiratory depressant effects of both classes, in this study, we investigated the effect of coadministration of Morphine and several widely used Benzodiazepines in the clinic on the rate of respiratory depression in rats. Methods & Materials Seventy adult male Wistar rats were randomly divided into 10 groups; Morphine, midazolam, diazepam, lorazepam, alprazolam, Morphine-midazolam, Morphine-diazepam, Morphine-lorazepam, and Morphine-alprazolam. Respiration signal was recorded using whole-body plethysmography 15 minutes after the intraperitoneal injection of the drugs. The respiratory pattern was examined using several parameters; the mean value of inter-breath interval and the respiratory rate, as well as the coefficient of variation and sample entropy analysis of inter-breath interval. Ethical Considerations This study was approved by the Ethics Committee of Arak University of Medical Sciences (Code: IR. ARAKMU. REC. 1397. 327). Results Analyzing respiratory data revealed that injecting the anxiolytic dose of alprazolam, and the combination of Morphine-alprazolam and Morphine-midazolam, altered the respiratory pattern. Such changes were associated with a decrease in the number of breaths and an increase in the inter-breath interval in the explored test animals, compared with the controls. The obtained data also indicated that Morphinemidazolam injection increased the variability of the Breathing pattern; such an alternation was associated with increased irregularity and decreased coefficient of variation of the inter-breath interval. Conclusion The present research results suggested that the short-term injection of Morphine-midazolam changes the respiratory pattern more severely than Morphine combined with other Benzodiazepines.

Cites

No record.

References

No record.

Cite

APA: Copy

ALIMORADIAN, ABBAS, Pazhoohan, Saeed, Mirzabeygi, Omid, & Naderinia, Kiana. (2021). Comparing Benzodiazepines-morphine-induced Respiratory Depression by Analyzing Respiratory Pattern in Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 23(6 (148) ), 850-852. SID. https://sid.ir/paper/690416/en

Vancouver: Copy

ALIMORADIAN ABBAS, Pazhoohan Saeed, Mirzabeygi Omid, Naderinia Kiana. Comparing Benzodiazepines-morphine-induced Respiratory Depression by Analyzing Respiratory Pattern in Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2021;23(6 (148) ):850-852. Available from: https://sid.ir/paper/690416/en

IEEE: Copy

ABBAS ALIMORADIAN, Saeed Pazhoohan, Omid Mirzabeygi, and Kiana Naderinia, “Comparing Benzodiazepines-morphine-induced Respiratory Depression by Analyzing Respiratory Pattern in Rats,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 23, no. 6 (148) , pp. 850–852, 2021, [Online]. Available: https://sid.ir/paper/690416/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops