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Information Journal Paper

Title

ANALYSIS OF OUTCOMES AND PROGNOSTIC FACTORS OF ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS TREATED BY MCP841 PROTOCOL: A REGIONAL CANCER CENTER EXPERIENCE

Pages

  0-0

Keywords

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) 

Abstract

 Background: A dramatic improvement in the survival of acute lymphoblastic leukemia (ALL) patients in the last three decades hasbeen observed. MCP 841 PROTOCOL is an old but effective tool with tolerable toxicities. The objective of this study was to estimate therelapse-free survival of ALL patients treated uniformly with MCP 841 PROTOCOL on the basis of various PROGNOSTIC FACTORS. Materialsand Methods: The study design was retrospective and it was conducted in a regional cancer center of NORTHWEST INDIA. Three hundredand ten ALL patients who underwent treatment with MCP 841 PROTOCOL and regular follow-up for up to 5 years were selected for thisstudy. Relapse-free survival was calculated by Kaplan–Meier analysis and Cox regression analysis was used to calculate the hazardsratio (HR) using Statistical Package for the Social Sciences (SPSS) software for windows version 20.0.Results: Fifty-four percentpatients were<15 years of age and 69% were males.53.2% patients were in remission at the end of 5 years of starting the treatment.Relapse-free survival at 5 years by Kaplan–Meir analysis for B-cell ALL was 62% [HR 0.67 {95% confidence interval (CI) 0.47-0.95} ]with patients with unknown lineage taken as reference] while for T cell it was 28% [HR 1.41 (95% CI 1.19-1.63), P 0.001]. Patientswith total leukocyte count (TLC)<1 lakh/cmm at presentation, relapse-free survival was 68% and those with TLC>1 lakh/cmmhad 41% survival [HR 2.14 (1.76-2.48) with, P<0.001].Conclusion: MCP 841 PROTOCOL is a useful tool for the treatment of ALL inchildren when more aggressive protocols can not be used.

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    APA: Copy

    KAPOOR, AKHIL, KALWAR, ASHOK, KUMAR, NARENDER, SINGHAL, MUKESH KUMAR, BENIWAL, SURENDER, & KUMAR, HARVINDRA SINGH. (2016). ANALYSIS OF OUTCOMES AND PROGNOSTIC FACTORS OF ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS TREATED BY MCP841 PROTOCOL: A REGIONAL CANCER CENTER EXPERIENCE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(1), 0-0. SID. https://sid.ir/paper/690589/en

    Vancouver: Copy

    KAPOOR AKHIL, KALWAR ASHOK, KUMAR NARENDER, SINGHAL MUKESH KUMAR, BENIWAL SURENDER, KUMAR HARVINDRA SINGH. ANALYSIS OF OUTCOMES AND PROGNOSTIC FACTORS OF ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS TREATED BY MCP841 PROTOCOL: A REGIONAL CANCER CENTER EXPERIENCE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(1):0-0. Available from: https://sid.ir/paper/690589/en

    IEEE: Copy

    AKHIL KAPOOR, ASHOK KALWAR, NARENDER KUMAR, MUKESH KUMAR SINGHAL, SURENDER BENIWAL, and HARVINDRA SINGH KUMAR, “ANALYSIS OF OUTCOMES AND PROGNOSTIC FACTORS OF ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS TREATED BY MCP841 PROTOCOL: A REGIONAL CANCER CENTER EXPERIENCE,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/690589/en

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