IN UTERO AND LACTATIONAL EFFECTS OF AQUEOUS FOENICULUM VULGARE (FENNEL) SEED EXTRACT ON PUBERTY TIMING, ESTRUS CYCLE AND SEXUAL BEHAVIOR IN MICE

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PARANDIN RAHMATOLLAH; YOUSOFVAND NAMDAR

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2018 | Volume:20 | Issue:11 (128) Page(s): 1-12

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Title

IN UTERO AND LACTATIONAL EFFECTS OF AQUEOUS FOENICULUM VULGARE (FENNEL) SEED EXTRACT ON PUBERTY TIMING, ESTRUS CYCLE AND SEXUAL BEHAVIOR IN MICE

Author(s)

PARANDIN RAHMATOLLAH | YOUSOFVAND NAMDAR | Issue Writer Certificate

Keywords

FENNELQ1

MICEQ2

PUBERTYQ1

REPRODUCTIVE FUNCTIONQ2

Abstract

Background: Several studies have shown that developmental exposure to phytoestrogens causes adverse effects on the REPRODUCTIVE FUNCTIONs. FENNEL as a phytoestrogen plant has a rich history in household use and traditional medicine. So, the current study was designed to investigate the effects of in utero and neonatal exposure with FENNEL on the PUBERTY onset, estrus cycle, reproductive organs and sexual behavior of their offspring.Materials and Methods: BALB/c MICE were injected intraperitoneally with 0 (control), 100, 200 and 400 (mg/kg bw) aqueous FENNEL seed extract (AFSE), daily from day 7 of gestation to postnatal day (PND) 7.Results: Vaginal opening (sign of PUBERTY onset) was advanced in 200 (p<0.01) and 400 AFSE (p<0.001) treated females. A 30 days vaginal smear check indicated that 200 or 400 AFSE treated MICE showed a prolonged estrus with decreased proestrus, estrus and metestrus stages and increased and diestrus stage and index. The ovary weight, number of corpora lutea and LH concentration decreased and uterus weight and estradiol concentration increased in the 200 or 400 treated MICE in PND 70.400 AFSE (p<0.01) treated females showed lordosis with a low lordosis quotient (LQ) when compared to the control group.Conclusion: These results suggest that developmental exposure to AFSE, due to its estrogenic compounds, it may cause the precocious PUBERTY, disrupted estrus cycle, altered weight of reproductive organs, hormonal imbalance and low lordosis behavior.

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APA: Copy

PARANDIN, RAHMATOLLAH, & YOUSOFVAND, NAMDAR. (2018). IN UTERO AND LACTATIONAL EFFECTS OF AQUEOUS FOENICULUM VULGARE (FENNEL) SEED EXTRACT ON PUBERTY TIMING, ESTRUS CYCLE AND SEXUAL BEHAVIOR IN MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(11 (128) ), 1-12. SID. https://sid.ir/paper/69074/en

Vancouver: Copy

PARANDIN RAHMATOLLAH, YOUSOFVAND NAMDAR. IN UTERO AND LACTATIONAL EFFECTS OF AQUEOUS FOENICULUM VULGARE (FENNEL) SEED EXTRACT ON PUBERTY TIMING, ESTRUS CYCLE AND SEXUAL BEHAVIOR IN MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;20(11 (128) ):1-12. Available from: https://sid.ir/paper/69074/en

IEEE: Copy

RAHMATOLLAH PARANDIN, and NAMDAR YOUSOFVAND, “IN UTERO AND LACTATIONAL EFFECTS OF AQUEOUS FOENICULUM VULGARE (FENNEL) SEED EXTRACT ON PUBERTY TIMING, ESTRUS CYCLE AND SEXUAL BEHAVIOR IN MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 11 (128) , pp. 1–12, 2018, [Online]. Available: https://sid.ir/paper/69074/en

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