INVESTIGATION OF THE EFFECTS OF RS137852599 SINGLE-NUCLEOTIDE POLYMORPHISM EXISTENCE IN DRUG RESISTANCE AGAINST TREATMENT WITH ENZALUTAMIDE IN INDIVIDUALS DIAGNOSED WITH PROSTATE CANCER IN ISFAHAN PROVINCE

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KAVIANI BITA; SAZEGAR HOSSEIN; ZIA JAHROMI NOOSHA; Mohamadi Farsani Farzaneh

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2018 | Volume:20 | Issue:11 (128) Page(s): 76-86

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Title

INVESTIGATION OF THE EFFECTS OF RS137852599 SINGLE-NUCLEOTIDE POLYMORPHISM EXISTENCE IN DRUG RESISTANCE AGAINST TREATMENT WITH ENZALUTAMIDE IN INDIVIDUALS DIAGNOSED WITH PROSTATE CANCER IN ISFAHAN PROVINCE

Author(s)

KAVIANI BITA | SAZEGAR HOSSEIN | ZIA JAHROMI NOOSHA | Mohamadi Farsani Farzaneh | Issue Writer Certificate

Keywords

DOCKINGQ2

DRUG RESISTANCEQ2

PROSTATE CANCERQ1

SINGLE NUCLEOTIDE POLYMORPHISMQ1

Abstract

Background: The aim of this study is to investigate the role of rs137852599 single-nucleotide polymorphism in the androgen receptor coding gene on DRUG RESISTANCE against treatment with Enzalutamide in individuals diagnosed with PROSTATE CANCER.Materials and Methods: In this case-control study, the ARMS-PCR analysis was conducted on androgen receptor coding gene in 50 patients diagnosed with PROSTATE CANCER with DRUG RESISTANCE and on 50 patients diagnosed with PROSTATE CANCER without DRUG RESISTANCE. The statistical analyses were performed using the GeNePop server and then the results were investigated by the SISA server.Results: The allele frequencies of A and C alleles in rs137852599 were 0.78 and 0.22 for drug resistant and 0.94 and 0.06 for non-drug resistance groups. The results indicated that there is a meaningful relationship between DRUG RESISTANCE and rs137852599 single-nucleotide polymorphism (p=0.020).Conclusion: The existence of single-nucleotide polymorphisms may result in DRUG RESISTANCE in individuals diagnosed with PROSTATE CANCER. Therefore, investigation of the existence of such polymorphisms can be effective in prescription of suitable drugs for these patients.

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APA: Copy

KAVIANI, BITA, SAZEGAR, HOSSEIN, ZIA JAHROMI, NOOSHA, & Mohamadi Farsani, Farzaneh. (2018). INVESTIGATION OF THE EFFECTS OF RS137852599 SINGLE-NUCLEOTIDE POLYMORPHISM EXISTENCE IN DRUG RESISTANCE AGAINST TREATMENT WITH ENZALUTAMIDE IN INDIVIDUALS DIAGNOSED WITH PROSTATE CANCER IN ISFAHAN PROVINCE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(11 (128) ), 76-86. SID. https://sid.ir/paper/69080/en

Vancouver: Copy

KAVIANI BITA, SAZEGAR HOSSEIN, ZIA JAHROMI NOOSHA, Mohamadi Farsani Farzaneh. INVESTIGATION OF THE EFFECTS OF RS137852599 SINGLE-NUCLEOTIDE POLYMORPHISM EXISTENCE IN DRUG RESISTANCE AGAINST TREATMENT WITH ENZALUTAMIDE IN INDIVIDUALS DIAGNOSED WITH PROSTATE CANCER IN ISFAHAN PROVINCE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;20(11 (128) ):76-86. Available from: https://sid.ir/paper/69080/en

IEEE: Copy

BITA KAVIANI, HOSSEIN SAZEGAR, NOOSHA ZIA JAHROMI, and Farzaneh Mohamadi Farsani, “INVESTIGATION OF THE EFFECTS OF RS137852599 SINGLE-NUCLEOTIDE POLYMORPHISM EXISTENCE IN DRUG RESISTANCE AGAINST TREATMENT WITH ENZALUTAMIDE IN INDIVIDUALS DIAGNOSED WITH PROSTATE CANCER IN ISFAHAN PROVINCE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 11 (128) , pp. 76–86, 2018, [Online]. Available: https://sid.ir/paper/69080/en

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