INVESTIGATION OF TIMP-1 GENE EXPRESSION IN PATIENTS WITH MULTIPLE SCLEROSIS(MS)

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KHOSHBIN NAZDIK MARZIEH; KHAZAEI KOOHPAR ZEINAB; SAYAD AREZOU

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Journal Paper

Paper Information

Journal: Journal of Arak University Medical Sciences Year:2017 | Volume:20 | Issue:6 (123) Page(s): 22-30

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Information Journal Paper

Title

INVESTIGATION OF TIMP-1 GENE EXPRESSION IN PATIENTS WITH MULTIPLE SCLEROSIS(MS)

Author(s)

KHOSHBIN NAZDIK MARZIEH | KHAZAEI KOOHPAR ZEINAB | SAYAD AREZOU | Issue Writer Certificate

Keywords

MMP-9Q1

MULTIPLE SCLEROSISQ1

REAL-TIME PCRQ1

TIMP-1Q1

Abstract

Background: Matrix metalloproteinases (MMPs) comprise a family of proteolytic enzymes.MMPs are capable of disrupting the blood-brain barrier (BBB), mediating the destruction of extracellular matrix and myelin components. Tissue inhibitors of metalloproteinases (TIMPs) are proteins which block the activitiy of MMPs. Matrix metalloproteinase-9 (MMP-9) facilitates T-cell migration into the CNS while the tissue inhibitor matrix metalloproteinase-1 (TIMP-1) inhibits MMP-9 actions. The aim of this study was to evaluate the expression of TIMP-1 gene (in RNA level) in blood cells of relapsingremitting MULTIPLE SCLEROSIS (RRMS) patients treated with IFNb.Materials and Methods: In this study, the expression level of TIMP-1 gene was investigated in blood cells of MS patients compared to healthy subjects by REAL-TIME PCR.Results: The RRMS patients manifested a lower expression level of TIMP-1 RNA than their normal counterparts, although the result was not significant (p=0.1).Conclusion: The results of this study showed that there was no linear correlation between TIMP-1 expression level and risk of Expanded Disability Status Scale of Kurtzke (EDSS); nor was there any significant correlation between expression status of TIMP-1 and duration of the disease. Further studies are recommended to compare TIMP-1 RNA in patients before and after taking IFN-beta.

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APA: Copy

KHOSHBIN NAZDIK, MARZIEH, KHAZAEI KOOHPAR, ZEINAB, & SAYAD, AREZOU. (2017). INVESTIGATION OF TIMP-1 GENE EXPRESSION IN PATIENTS WITH MULTIPLE SCLEROSIS(MS). ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(6 (123)), 22-30. SID. https://sid.ir/paper/69099/en

Vancouver: Copy

KHOSHBIN NAZDIK MARZIEH, KHAZAEI KOOHPAR ZEINAB, SAYAD AREZOU. INVESTIGATION OF TIMP-1 GENE EXPRESSION IN PATIENTS WITH MULTIPLE SCLEROSIS(MS). ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(6 (123)):22-30. Available from: https://sid.ir/paper/69099/en

IEEE: Copy

MARZIEH KHOSHBIN NAZDIK, ZEINAB KHAZAEI KOOHPAR, and AREZOU SAYAD, “INVESTIGATION OF TIMP-1 GENE EXPRESSION IN PATIENTS WITH MULTIPLE SCLEROSIS(MS),” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 6 (123), pp. 22–30, 2017, [Online]. Available: https://sid.ir/paper/69099/en

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