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Information Journal Paper

Title

Cinnamon effects on blood pressure and metabolic profile: A double-blind, randomized, placebo-controlled trial in patients with stage 1 hypertension

Pages

  91-100

Abstract

 Objective: Cinnamon effect on blood pressure remains controversial. The present pilot study assessed Cinnamon effect on blood pressure, and metabolic profile of stage 1 Hypertension patients (S1HTN). Materials and Methods: This double-blind placebo-controlled randomized trial was conducted between June and October 2019, in Mashhad, Iran. Study inclusion criteria comprised S1HTN diagnosis, based on 24-hour ambulatory blood pressure monitoring (ABPM). Subjects were randomly assigned to two groups: Cinnamon group (capsule, 1500 mg/day, 90 days) and placebo group. On days 0 and 90, ABPM derived systolic and diastolic blood pressure (SBP and DBP, respectively), blood lipid profile, and fasting blood sugar (FBS) were recorded. Results: The two groups did not differ significantly regarding vascular risk factors, educational status, lipid profile and blood pressure at baseline, except for lower HDL-c in Cinnamon group (p=0. 03). On day 90, there was no significant difference between two study groups for lipid profile and blood pressure. A statistically significant decrease in mean 24-hr SBP and mean day SBP was observed in the Cinnamon group, while mean night SBP and mean night DBP were decreased significantly in the placebo group after 90 days. A statistically significant decrease in mean change of day value of SBP was found in the Cinnamon group, compared to the placebo. On day 90, FBS remained practically unchanged but a significant increase in HDL-c (5. 8 unit; p=0. 01) and a significant decrease in LDL-c levels (17. 7 unit; p=0. 009) were observed in the Cinnamon group compared to placebo group. Conclusion: Cinnamon caused a statistically significant decrease in mean ambulatory SBP but in a clinically moderate way, and lipid profile was significantly improved. Therefore, Cinnamon might be considered a complementary treatment in subjects with S1HTN.

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    Cite

    APA: Copy

    Shirzad, Fatemeh, MOROVATDAR, NEGAR, REZAEE, RAMIN, & ABDOLLAHI MOGHADAM, ALIREZA. (2021). Cinnamon effects on blood pressure and metabolic profile: A double-blind, randomized, placebo-controlled trial in patients with stage 1 hypertension. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(1), 91-100. SID. https://sid.ir/paper/691008/en

    Vancouver: Copy

    Shirzad Fatemeh, MOROVATDAR NEGAR, REZAEE RAMIN, ABDOLLAHI MOGHADAM ALIREZA. Cinnamon effects on blood pressure and metabolic profile: A double-blind, randomized, placebo-controlled trial in patients with stage 1 hypertension. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(1):91-100. Available from: https://sid.ir/paper/691008/en

    IEEE: Copy

    Fatemeh Shirzad, NEGAR MOROVATDAR, RAMIN REZAEE, and ALIREZA ABDOLLAHI MOGHADAM, “Cinnamon effects on blood pressure and metabolic profile: A double-blind, randomized, placebo-controlled trial in patients with stage 1 hypertension,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 1, pp. 91–100, 2021, [Online]. Available: https://sid.ir/paper/691008/en

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