EFFECT OF ONDANSETRON ON PRURITUS IN HEMODIALYSIS PATIENTS

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MIRNEZAMI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Journal of Arak University Medical Sciences Year:2013 | Volume:16 | Issue:3 (72) Page(s): 80-84

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Title

EFFECT OF ONDANSETRON ON PRURITUS IN HEMODIALYSIS PATIENTS

Author(s)

MIRNEZAMI M. | Issue Writer Certificate

Keywords

ONDANSETRONQ2

PRURITUSQ2

RENAL DIALYSISQ2

RENAL INSUFFICIENCYQ2

Abstract

Background: PRURITUS is the most distressing symptom in hemodialysis patients. Its etiology has not yet been delineated; thus, there are no good therapeutic options. Serotonin has been reported to be a mediator of uremic PRURITUS while ONDANSETRON is a potent and selective inhibitor of 5-HT3 receptors. The aim of this study was to evaluate the effect of ONDANSETRON on uremic PRURITUS in hemodialysis patients.Materials and Methods: In this randomized double-blind clinical trial, 70 patients undergoing hemodialysis with moderate and severe itching were enrolled. They were randomly divided into two groups: one group received ONDANSETRON 8 mg three times daily and the other group was given loratadine 10 mg two times a day for 2 weeks. PRURITUS scores were recorded by the patients and the mean scores were compared before and after intervention.Results: Changes in VAS scores after treatment with ONDANSETRON and loratadin were both significant (P=0.001), but the difference between ONDANSETRON and loratadin was not significant (P=0.8).Conclusions: The results showed that ONDANSETRON was as effective as loratadin in controlling renal itch.

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APA: Copy

MIRNEZAMI, M.. (2013). EFFECT OF ONDANSETRON ON PRURITUS IN HEMODIALYSIS PATIENTS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 16(3 (72)), 80-84. SID. https://sid.ir/paper/69111/en

Vancouver: Copy

MIRNEZAMI M.. EFFECT OF ONDANSETRON ON PRURITUS IN HEMODIALYSIS PATIENTS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;16(3 (72)):80-84. Available from: https://sid.ir/paper/69111/en

IEEE: Copy

M. MIRNEZAMI, “EFFECT OF ONDANSETRON ON PRURITUS IN HEMODIALYSIS PATIENTS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 16, no. 3 (72), pp. 80–84, 2013, [Online]. Available: https://sid.ir/paper/69111/en

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