A STUDY ON EFFECT OF METIMAZOLE-LEVOTHYROXINE COMBINED THERAPY COMPARED WITH METIMAZOLE ALONE IN PROLOGED REMISSION OF GRAVE'S DISEASE

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FANI A.

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Journal: Journal of Arak University Medical Sciences Year:2002 | Volume:4 | Issue:4 (17) Page(s): 1-7

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Title

A STUDY ON EFFECT OF METIMAZOLE-LEVOTHYROXINE COMBINED THERAPY COMPARED WITH METIMAZOLE ALONE IN PROLOGED REMISSION OF GRAVE'S DISEASE

Author(s)

FANI A. | Issue Writer Certificate

Keywords

THYROTOXICOSEQ4

CLINICAL TRIALQ4

METIMAZOLEQ4

LEVOTHYROXINEQ4

Abstract

Introduction: Grave's disease is the most prevalent form of thyrotoxicosis (60-80%), which is caused by an autoimmune reaction. Treating with antithyroid drugs usually lead to prolonged remission in 30%-40% of cases. Paradoxically it is assumed that adding thyroid hormones to the therapy would give more benefits because of preventing the feedback of TSH to further Stimulate the thyroid gland after using antithyroid drug. In this study we compared the effect of adding LEVOTHYROXINE to the routine therapy in reducing the relapse of thyrotoxcosis. Materials and Methods: This was a "Clinical-Trial" study in which we compared the two regimens of METIMAZOLE plus LEVOTHYROXINE (regimen A), with METIMAZOLE alone (regimen B), in reducing the grave's disease relapses.Results: In this 7 years study, 262 patients finished the trial. 137 were assigning as group A and 125 cases were assigned to group B. randomly. Graves was most prevalent in 3 rd to 5th decades. 52.3% of disease had grade II Goiter. The Rate of relapse was 36A% in group A and 61.6% in group B, during 3 years after discontinuation of therapy. Conclusion: The peak age of prevalence was found out to be lower than eastern reports (3-5 in comparison to 5-6 decades). Clinical manifestations were not significantly different from other studies. The two regimen results were compared by OR method and calculating OR, in grade I Goiter was 0.27 and in grade II was 0.29, grade III was 0.32, which has a meaningful difference and implies that regimen A is effective in reducing the prolonged rate of relapse but in grade IV Goiter, there is not significant difference in relapse in two group.

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APA: Copy

FANI, A.. (2002). A STUDY ON EFFECT OF METIMAZOLE-LEVOTHYROXINE COMBINED THERAPY COMPARED WITH METIMAZOLE ALONE IN PROLOGED REMISSION OF GRAVE'S DISEASE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 4(4 (17)), 1-7. SID. https://sid.ir/paper/69138/en

Vancouver: Copy

FANI A.. A STUDY ON EFFECT OF METIMAZOLE-LEVOTHYROXINE COMBINED THERAPY COMPARED WITH METIMAZOLE ALONE IN PROLOGED REMISSION OF GRAVE'S DISEASE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2002;4(4 (17)):1-7. Available from: https://sid.ir/paper/69138/en

IEEE: Copy

A. FANI, “A STUDY ON EFFECT OF METIMAZOLE-LEVOTHYROXINE COMBINED THERAPY COMPARED WITH METIMAZOLE ALONE IN PROLOGED REMISSION OF GRAVE'S DISEASE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 4, no. 4 (17), pp. 1–7, 2002, [Online]. Available: https://sid.ir/paper/69138/en

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