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Information Journal Paper

Title

EXPRESSION OF PRO-INFLAMMATORY GENES IN LESIONS, SPLEENS AND BLOOD NEUTROPHILS AFTER BURN INJURIES IN MICE TREATED WITH SILVER SULFODIAZINE

Pages

  769-775

Abstract

 Objective(s): It is now supposed that cytokines released during the BURN injuries have a great impact on the immunological and pathological responses after the BURN. The main objective of this study was to investigate the expression of some PRO-INFLAMMATORY genes in the WOUND, SPLEEN and blood NEUTROPHILS during the healing process of BURN WOUNDs in a murine model.Materials and Methods: The expression of ten PRO-INFLAMMATORY genes were examined in WOUNDs, SPLEENs and blood NEUTROPHILS of mice with BURN injuries treated with either SILVER SULFODIAZINE or phosphate-buffered saline (PBS) using RT-PCR at the end of the first and second weeks after injuries.Results: None of the PRO-INFLAMMATORY genes were expressed in the skin, SPLEEN and blood NEUTROPHILS of healthy mice. In the group control, IL-12P35, IL-12P40, CCR5, IL-1b and IFN- g were expressed in the SPLEEN and blood NEUTROPHILS in the first week. Instead, CCL5, CCR5, IL-1b and IFN- g were expressed in the WOUND, but in the second week, the expression of the genes became similar. In the test group, in the first week, TNF-a, IL-12P35, IL-12P40 and IL-1b were expressed in the lesions, CCL4, IL-1a, IL-12P35, IL-12P40, CCR5 and IFN-g were expressed in the SPLEEN and no PRO-INFLAMMATORY gene expression was detected in blood NEUTROPHILS.Conclusion: IL-1b and IFN- g are expressed in WOUND, SPLEEN and NEUTROPHILS of untreated mice, but not in SILVER SULFODIAZINE treated mice. Hence, treatment with SILVER SULFODIAZINE suppressed the expression of PRO-INFLAMMATORY genes in some stages of healing.

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    • Cite

    APA: Copy

    AKHZARI, SOHEYLA, REZVAN, HOSSEIN, & ZOLHAVARIEH, SEYED MASOUD. (2017). EXPRESSION OF PRO-INFLAMMATORY GENES IN LESIONS, SPLEENS AND BLOOD NEUTROPHILS AFTER BURN INJURIES IN MICE TREATED WITH SILVER SULFODIAZINE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(7), 769-775. SID. https://sid.ir/paper/691484/en

    Vancouver: Copy

    AKHZARI SOHEYLA, REZVAN HOSSEIN, ZOLHAVARIEH SEYED MASOUD. EXPRESSION OF PRO-INFLAMMATORY GENES IN LESIONS, SPLEENS AND BLOOD NEUTROPHILS AFTER BURN INJURIES IN MICE TREATED WITH SILVER SULFODIAZINE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(7):769-775. Available from: https://sid.ir/paper/691484/en

    IEEE: Copy

    SOHEYLA AKHZARI, HOSSEIN REZVAN, and SEYED MASOUD ZOLHAVARIEH, “EXPRESSION OF PRO-INFLAMMATORY GENES IN LESIONS, SPLEENS AND BLOOD NEUTROPHILS AFTER BURN INJURIES IN MICE TREATED WITH SILVER SULFODIAZINE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 7, pp. 769–775, 2017, [Online]. Available: https://sid.ir/paper/691484/en

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