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Information Journal Paper

Title

THERAPEUTIC POTENTIAL OF GENISTEIN IN OVARIECTOMY-INDUCED PANCREATIC INJURY IN DIABETIC RATS: THE REGULATION OF MAPK PATHWAY AND APOPTOSIS

Pages

  1009-1015

Abstract

 Objective(s): GENISTEIN, as a phytoestrogen found in legumes, has several biological activities in general and anti-diabetic activity particularly. In this study, we investigated the effect of GENISTEIN on proteins involved in b-cell proliferation, survival and apoptosis to further reveal its anti-diabetic potential in the ovariectomized diabetic rat.Materials and Methods: We used three-month-old female Wistar rats that either underwent OVARIECTOMY (OVX) or received a sham surgery (Sham). In a subsequent series of experiments, OVX rats received high-fat diet and low dose STZ to induce DIABETES (OVX.D) and GENISTEIN treatment (OVX.D.G). Western blot analysis was used for the assessment of phosphorylation of ERK1/2 and AKT and expression of BCL-2 and CASPASE-3 in pancreas tissue. Hematoxylin-Eosin (H& E) staining was used for histopathological assessment.Results: GENISTEIN induced AKT and ERK1/2 phosphorylation protein expression of BCL-2 in the pancreas. In addition, GENISTEIN suppressed protein level of CASPASE-3. Administration of GENISTEIN significantly improved hyperglycemia in ovariectomized diabetic rat, concomitant with improved islet b-cell morphology and mass.Conclusion: These findings suggest that the beneficial antidiabetic effect of GENISTEIN partially mediated by directly modulating pancreatic b-cell function via activation of the AKT, ERK1/2, and BCL-2, as cell survival and anti-apoptotic factors, and decreasing of proapoptotic CASPASE-3.

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    APA: Copy

    YOUSEFI, HADI, KARIMI, POURAN, ALIHEMMATI, ALIREZA, ALIPOUR, MOHMMAD REZA, HABIBI, PARISA, & AHMADIASL, NASSER. (2017). THERAPEUTIC POTENTIAL OF GENISTEIN IN OVARIECTOMY-INDUCED PANCREATIC INJURY IN DIABETIC RATS: THE REGULATION OF MAPK PATHWAY AND APOPTOSIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(9), 1009-1015. SID. https://sid.ir/paper/691495/en

    Vancouver: Copy

    YOUSEFI HADI, KARIMI POURAN, ALIHEMMATI ALIREZA, ALIPOUR MOHMMAD REZA, HABIBI PARISA, AHMADIASL NASSER. THERAPEUTIC POTENTIAL OF GENISTEIN IN OVARIECTOMY-INDUCED PANCREATIC INJURY IN DIABETIC RATS: THE REGULATION OF MAPK PATHWAY AND APOPTOSIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(9):1009-1015. Available from: https://sid.ir/paper/691495/en

    IEEE: Copy

    HADI YOUSEFI, POURAN KARIMI, ALIREZA ALIHEMMATI, MOHMMAD REZA ALIPOUR, PARISA HABIBI, and NASSER AHMADIASL, “THERAPEUTIC POTENTIAL OF GENISTEIN IN OVARIECTOMY-INDUCED PANCREATIC INJURY IN DIABETIC RATS: THE REGULATION OF MAPK PATHWAY AND APOPTOSIS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 9, pp. 1009–1015, 2017, [Online]. Available: https://sid.ir/paper/691495/en

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