High Expression of TWIST-1 in the Chronic Myeloid Leukemia Patients with T315I Mutation

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HEIDARI NAZANIN; Noroozi Fatemeh; SAKI NAJMALDIN

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Journal Paper

Paper Information

Journal: Jentashapir Journal of Cellular and Molecular Biology Year:2021 | Volume:12 | Issue:3 Page(s): 0-0

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Title

High Expression of TWIST-1 in the Chronic Myeloid Leukemia Patients with T315I Mutation

Author(s)

HEIDARI NAZANIN | Noroozi Fatemeh | SAKI NAJMALDIN | Issue Writer Certificate

Keywords

Chronic Myelogenous Leukemia

BCR-ABL1

TWIST-1

T315I Mutation

Abstract

Background: Among the known ABL mutations in chronic myeloid leukemia (CML), T315I is of particular importance. The T315I Mutation may develop resistant cells that increase disease progression. TWIST-1 expression is impaired in patients with increased drug resistance. Objectives: The current study aimed to measure the expression of TWIST-1 gene in CML patients to investigate its association with T315I Mutation. Methods: Peripheral blood samples were taken from 40 CML patients. The expression of TWIST-1 and BCR-ABL1 genes was quantified by real-time polymerase chain reaction (PCR). The gene expression was evaluated by REST software. cDNA was used for amplification refractory mutation system (ARMS)-PCR reaction. Results: Of the 40 patients (age range: 19-72 years) participating in the study, 23 (57. 7%) were female, and 17 (42. 5%) were male. The expression of TWIST-1 gene was 43 184. 09-fold. The T315I Mutation was detected in 3 (7. 5%) patients. Conclusions: According to our results, the TWIST-1 gene expression in patients with T315I Mutation was significantly higher than patients without that mutation.

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References

Effects of Twist1 on drug resistance of chronic myeloid leukemia cells through the PI3K/AKT signaling pathway

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APA: Copy

HEIDARI, NAZANIN, Noroozi, Fatemeh, & SAKI, NAJMALDIN. (2021). High Expression of TWIST-1 in the Chronic Myeloid Leukemia Patients with T315I Mutation. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), 12(3), 0-0. SID. https://sid.ir/paper/692278/en

Vancouver: Copy

HEIDARI NAZANIN, Noroozi Fatemeh, SAKI NAJMALDIN. High Expression of TWIST-1 in the Chronic Myeloid Leukemia Patients with T315I Mutation. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH)[Internet]. 2021;12(3):0-0. Available from: https://sid.ir/paper/692278/en

IEEE: Copy

NAZANIN HEIDARI, Fatemeh Noroozi, and NAJMALDIN SAKI, “High Expression of TWIST-1 in the Chronic Myeloid Leukemia Patients with T315I Mutation,” JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), vol. 12, no. 3, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/692278/en

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