Effects of Vitamin D Supplementation on Inflammatory Markers in Multiple Sclerosis Patients: A Systematic Review and Meta-analysis

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Mehrabadi Shima; ZAHEDI ELHAM

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Journal Paper

Paper Information

Journal: Journal of Archives in Military Medicine Year:2021 | Volume:9 | Issue:1 Page(s): 0-0

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Title

Effects of Vitamin D Supplementation on Inflammatory Markers in Multiple Sclerosis Patients: A Systematic Review and Meta-analysis

Author(s)

Mehrabadi Shima | ZAHEDI ELHAM | Issue Writer Certificate

Keywords

Vitamin D

Multiple Sclerosis

Inflammation

Systematic Review

Meta-analysis

Abstract

Context: Numerous studies have indicated that Vitamin D can modulate the immune system and plays an important role in regulating immune cells’ functions. Some clinical studies have assessed the effect of Vitamin D supplementation on cytokine markers in Multiple Sclerosis (MS) as a disease in which the immune system’ s function is disrupted. Evidence Acquisition: This study was designed to assess randomized clinical trial studies evaluating the overall effect of Vitamin D on the levels of IL-10, IL-17, and IFN- in MS patients. Methods: We searched PubMed and Scopus online databases up to November 2020 for relevant randomized clinical trial studies by using certain keywords. Eight studies from 273 articles, with a total sample of 443 participants, were considered Results: The Meta-analysis indicated that Vitamin D consumption did not significantly change the levels of IL-10 (WMD:-174. 56, 95% CI:-373. 10 to 23. 98), IL-17 (WMD:-0. 11, 95% CI:-0. 54. 10 to 0. 33), or IFN- (WMD: 61. 47, 95% CI: 43. 96 to 78. 98) in MS patients. Conclusions: Further clinical trials are warranted to evaluate the effects of Vitamin D supplement on IL-10 and IL-17, and INF levels in MS patients.

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APA: Copy

Mehrabadi, Shima, & ZAHEDI, ELHAM. (2021). Effects of Vitamin D Supplementation on Inflammatory Markers in Multiple Sclerosis Patients: A Systematic Review and Meta-analysis. JOURNAL OF ARCHIVES IN MILITARY MEDICINE, 9(1), 0-0. SID. https://sid.ir/paper/692320/en

Vancouver: Copy

Mehrabadi Shima, ZAHEDI ELHAM. Effects of Vitamin D Supplementation on Inflammatory Markers in Multiple Sclerosis Patients: A Systematic Review and Meta-analysis. JOURNAL OF ARCHIVES IN MILITARY MEDICINE[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/692320/en

IEEE: Copy

Shima Mehrabadi, and ELHAM ZAHEDI, “Effects of Vitamin D Supplementation on Inflammatory Markers in Multiple Sclerosis Patients: A Systematic Review and Meta-analysis,” JOURNAL OF ARCHIVES IN MILITARY MEDICINE, vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/692320/en

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