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Information Journal Paper

Title

A Case-control Study of Urinary Tract Infection, 25-Hydroxyvitamin D Status and Associated Inflammatory and Regulatory Responses

Pages

  51-60

Abstract

 Background: Vitamin D plays a key role in the modulation of numerous immune functions against infectious agents. We aimed to explore the association between serum 25‑ hydroxyVitamin D (25[OH] D) levels and Cytokine responses, along with hematological changes, in patients with Urinary tract infection (UTI). Materials and Methods: Vitamin D level, Cytokines (interferon [IFN]− γ , interleukin [IL]− 4, IL− 6, IL– 10, IL− 17A, tumor necrosis factor [TNF]− α , and transforming growth factor [TGF]− β ), hematological indices (neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR], neutrophil-to-monocyte ratio [NMR], platelet-to-lymphocyte ratio [PLR], and mean platelet volume [MPV]), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated in a case-control human study included 65 patients and 45 controls. Results: Among the enhanced Cytokine levels in patients, the Cytokines IFN-γ , IL-17A, and IL-10 had a significant association with 25(OH)D, but not IL-6, TNF-α , and TGF-β . The IL-4 levels remained unchanged. By comparing hematological indices, we found the association of increased NLR and MLR with 25(OH)D and the Cytokines IFN-γ and IL-17A, along with a decrease in the PLR without showing such an association. The NMR did not show any significant difference. The platelet count showed an association with IL-6, IL-17A, and TGF-β , but the association of MPV with 25(OH)D was significant. The ESR results exhibited statistically non-significant differences. CRP elevation was directly associated with IL-6 and IL-17A, but not with 25(OH)D. Conclusion: 25(OH)D-mediated inflammatory Cytokine milieu might alter the proportion and function of peripheral blood cells in a regulated manner to support bacterial clearance which needs further studies to be validated.

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    APA: Copy

    PIRDEL, LEILA, & Pirdel, Manijeh. (2021). A Case-control Study of Urinary Tract Infection, 25-Hydroxyvitamin D Status and Associated Inflammatory and Regulatory Responses. RESEARCH IN MOLECULAR MEDICINE, 9(1), 51-60. SID. https://sid.ir/paper/692399/en

    Vancouver: Copy

    PIRDEL LEILA, Pirdel Manijeh. A Case-control Study of Urinary Tract Infection, 25-Hydroxyvitamin D Status and Associated Inflammatory and Regulatory Responses. RESEARCH IN MOLECULAR MEDICINE[Internet]. 2021;9(1):51-60. Available from: https://sid.ir/paper/692399/en

    IEEE: Copy

    LEILA PIRDEL, and Manijeh Pirdel, “A Case-control Study of Urinary Tract Infection, 25-Hydroxyvitamin D Status and Associated Inflammatory and Regulatory Responses,” RESEARCH IN MOLECULAR MEDICINE, vol. 9, no. 1, pp. 51–60, 2021, [Online]. Available: https://sid.ir/paper/692399/en

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