RELATIONSHIPS OF MMP-9 AND TIMP-1 PROTEINS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS

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LI YANGXUE; LU YANG; ZHAO ZHUO; WANG JUNNAN; LI JIANXIN; WANG WEIMING; LI SHUMEI; SONG LEI

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2016 | Volume:21 | Issue:1 Page(s): 0-0

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Title

RELATIONSHIPS OF MMP-9 AND TIMP-1 PROTEINS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS

Author(s)

Keywords

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

MATRIX METALLOPROTEINASE

MATRIX METALLOPROTEINASE-9

META ANALYSIS

TISSUE INHIBITOR OF METALLOPROTEINASE

TISSUE INHIBITOR OF METALLOPROTEINASE-1

PATHOGENESIS

Abstract

Background: We performed this meta-analysis in order to collect all the relevant studies to clarify the correlations of matrixmetalloproteinase-9 (MMP-9) and TISSUE INHIBITOR OF METALLOPROTEINASE-1 (TIMP-1) with CHRONIC OBSTRUCTIVE PULMONARY DISEASE(COPD). Materials and Methods: After a literature search in electronic databases, pertinent case-control studies investigating thecorrelations of MMP-9 and TIMP-1 protein expressions within a COPD setting were enrolled based on our strict inclusion andexclusion criteria. We used key words such as “CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ” “COPD” or “COAD” or “chronic obstructiveairway disease” and “matrix metalloproteinases” or “MMPs” to make a searching strategy in this study. STATA software (version12.0, Stata Corporation, College Station, TX, USA) was utilized for statistical analysis.Results: A total of 20 studies were enrolledinto this meta-analysis including 923 COPD patients and 641 healthy controls. The findings of this meta-analysis revealed that serumexpression levels of MMP-9 and TIMP-1 protein in COPD patients were higher than those of healthy controls (MMP-9: SMD=1.44, 95%CI=0.85 ~ 2.04, P<0.001; TIMP-1: SMD=3.53, 95% CI=2.31 ~ 4.75, P<0.001). Subgroup analysis based on ethnicity revealedthat both Caucasians and Asian COPD patients exhibited higher MMP-9 and TIMP-1 serum protein levels than healthy controls(MMP-9: SMD=0.81, 95%CI=0.15~1.48, P=0.016; TIMP-1: SMD=4.43, 95%CI=1.98 ~ 6.87, P=0.016) and in Caucasians (MMP-9: SMD=2.30, 95%CI=1.21 ~ 3.38, P<0.001; TIMP-1: SMD=2.86, 95%CI=1.47 ~ 4.24, P<0.001).Conclusion: The result of thismeta-analysis indicates that elevated levels of MMP-9 and TIMP-1 proteins may be correlated with the PATHOGENESIS of COPD, andthe two proteins may represent important biological markers for the early diagnosis of COPD.

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APA: Copy

LI, YANGXUE, LU, YANG, ZHAO, ZHUO, WANG, JUNNAN, LI, JIANXIN, WANG, WEIMING, LI, SHUMEI, & SONG, LEI. (2016). RELATIONSHIPS OF MMP-9 AND TIMP-1 PROTEINS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(1), 0-0. SID. https://sid.ir/paper/692433/en

Vancouver: Copy

LI YANGXUE, LU YANG, ZHAO ZHUO, WANG JUNNAN, LI JIANXIN, WANG WEIMING, LI SHUMEI, SONG LEI. RELATIONSHIPS OF MMP-9 AND TIMP-1 PROTEINS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(1):0-0. Available from: https://sid.ir/paper/692433/en

IEEE: Copy

YANGXUE LI, YANG LU, ZHUO ZHAO, JUNNAN WANG, JIANXIN LI, WEIMING WANG, SHUMEI LI, and LEI SONG, “RELATIONSHIPS OF MMP-9 AND TIMP-1 PROTEINS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/692433/en

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