COMPARISON OF THE EFFECTS OF METFORMIN, FLUTAMIDE PLUS ORAL CONTRACEPTIVES, AND SIMVASTATIN ON THE METABOLIC CONSEQUENCES OF POLYCYSTIC OVARY SYNDROME

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MEHRABIAN FERDOUS; GHASEMI TEHRANI HATAV; MOHAMADKHANI MAHBOOBE; MOEINODDINI MARYAM; KARIMZADEH POOYA

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2016 | Volume:21 | Issue:1 Page(s): 0-0

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Title

COMPARISON OF THE EFFECTS OF METFORMIN, FLUTAMIDE PLUS ORAL CONTRACEPTIVES, AND SIMVASTATIN ON THE METABOLIC CONSEQUENCES OF POLYCYSTIC OVARY SYNDROME

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Keywords

FLUTAMIDE

METFORMIN

ORAL CONTRACEPTIVES (OCS)

POLYCYSTIC OVARY SYNDROME (PCOS)

SIMVASTATIN

Abstract

Background: Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women of reproductive ages. It isassociated with a range of disorders, such as dyslipidemia, hypertension, insulin resistance (IR), compensatory hyperinsulinemia, gestational, and type 2 diabetes, and increased risk of cardiovascular morbidity. There are different treatments available for PCOS. Thepurpose of this study was to determine and compare the effects of METFORMIN, FLUTAMIDE plus oral contraceptives (OCs), and SIMVASTATINon the metabolic consequences of PCOS. Materials and Methods: This study was a single-blind clinical trial. The subjects were selectedfrom a group of patient with PCOS and metabolic syndrome, who were referred to the midwifery clinic of Al-Zahra Hospital andBeheshti Hospital, Isfahan, Iran. A total of 111 subjects were randomly assigned to three groups: METFORMIN, FLUTAMIDE plus OCs, andsimvastatin groups. The measurements were performed at baseline and after 6 months of therapy. Paired t-test, analysis of variance(ANOVA), and chi-square test were applied in this study.Results: A total of 102 subjects were analyzed in this study, 34 subjects wereallotted in each group. The prevalence of IR was statistically different between three groups (P-value=0.001). After a 6-month course, METFORMIN showed larger reduction in fasting blood sugar (FBS) level (P-value<0.001). However, except for METFORMIN, two othertreatments reduced C-reactive protein (CRP) level significantly (both P-values<0.001). The level of triglycerides (TGs) decreasedconsiderably in all groups (all P-values<0.001). Both METFORMIN and SIMVASTATIN decreased BMI significantly (both P-values<0.001).None of the treatments changed high-density lipoprotein (HDL) level (all P-values>0.05).Conclusion: METFORMIN performed betterin FBS reduction. SIMVASTATIN had better performance in terms of reducing TG level and waist circumference.

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APA: Copy

MEHRABIAN, FERDOUS, GHASEMI TEHRANI, HATAV, MOHAMADKHANI, MAHBOOBE, MOEINODDINI, MARYAM, & KARIMZADEH, POOYA. (2016). COMPARISON OF THE EFFECTS OF METFORMIN, FLUTAMIDE PLUS ORAL CONTRACEPTIVES, AND SIMVASTATIN ON THE METABOLIC CONSEQUENCES OF POLYCYSTIC OVARY SYNDROME. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(1), 0-0. SID. https://sid.ir/paper/692434/en

Vancouver: Copy

MEHRABIAN FERDOUS, GHASEMI TEHRANI HATAV, MOHAMADKHANI MAHBOOBE, MOEINODDINI MARYAM, KARIMZADEH POOYA. COMPARISON OF THE EFFECTS OF METFORMIN, FLUTAMIDE PLUS ORAL CONTRACEPTIVES, AND SIMVASTATIN ON THE METABOLIC CONSEQUENCES OF POLYCYSTIC OVARY SYNDROME. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(1):0-0. Available from: https://sid.ir/paper/692434/en

IEEE: Copy

FERDOUS MEHRABIAN, HATAV GHASEMI TEHRANI, MAHBOOBE MOHAMADKHANI, MARYAM MOEINODDINI, and POOYA KARIMZADEH, “COMPARISON OF THE EFFECTS OF METFORMIN, FLUTAMIDE PLUS ORAL CONTRACEPTIVES, AND SIMVASTATIN ON THE METABOLIC CONSEQUENCES OF POLYCYSTIC OVARY SYNDROME,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/692434/en

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