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Information Journal Paper

Title

MELATONIN AMELIORATES THE PRODUCTION OF COX-2, INOS, AND THE FORMATION OF 8-OHDG IN NON-TARGETED LUNG TISSUE AFTER PELVIC IRRADIATION (SHORT COMMUNICATION)

Pages

  324-331

Abstract

 In this study, we evaluated the bystander effect of radiation on the regulation of CYCLOOXYGENASE-2 (COX-2), INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS), and 8-HYDROXYDEOXYGUANOSINE (8-OHdG) in lung tissues of Sprague-Dawley rats with and without pre-administration of MELATONIN. A 2×2 cm2 area of the pelvis of male Sprague-Dawley rats with and without pre-administration of MELATONIN (100 mg/kg) by oral and intraperitoneal injection was irradiated with a 3 Gy dose of 1.25 MeV γ-rays. Alterations in the levels of COX-2, iNOS, and 8-OHdG in the out-of-field lung areas of the animals were detected by enzyme immunoassay. The bystander effect significantly increased COX-2, iNOS, and 8-OHdG levels in non-targeted lung tissues (P<0.05). MELATONIN ameliorated the bystander effect of radiation and significantly reduced the level of all examined biomarkers (P<0.05). The results indicated that the ameliorating effect of a pre-intraperitoneal (IP) injection of MELATONIN was noticeably greater compared to oral pre-administration. Our findings revealed that the bystander effect of radiation could induce oxidative DNA damage and increase the levels of imperative COX-2 and iNOS in non-targeted lung tissues. Interestingly, MELATONIN could modulate the indirect destructive effect of radiation and reduce DNA damage in non-targeted cells.

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    APA: Copy

    FARDID, REZA, SALAJEGHEH, ASHKAN, MOSLEH SHIRAZI, MOHAMMAD AMIN, SHARIFZADEH, SEDIGHEH, OKHOVAT, MOHAMMAD ALI, NAJAFI, MASOUD, REZAEYAN, ABOLHASAN, & ABASZADEH, AKBAR. (2017). MELATONIN AMELIORATES THE PRODUCTION OF COX-2, INOS, AND THE FORMATION OF 8-OHDG IN NON-TARGETED LUNG TISSUE AFTER PELVIC IRRADIATION (SHORT COMMUNICATION). CELL JOURNAL (YAKHTEH), 19(2), 324-331. SID. https://sid.ir/paper/692524/en

    Vancouver: Copy

    FARDID REZA, SALAJEGHEH ASHKAN, MOSLEH SHIRAZI MOHAMMAD AMIN, SHARIFZADEH SEDIGHEH, OKHOVAT MOHAMMAD ALI, NAJAFI MASOUD, REZAEYAN ABOLHASAN, ABASZADEH AKBAR. MELATONIN AMELIORATES THE PRODUCTION OF COX-2, INOS, AND THE FORMATION OF 8-OHDG IN NON-TARGETED LUNG TISSUE AFTER PELVIC IRRADIATION (SHORT COMMUNICATION). CELL JOURNAL (YAKHTEH)[Internet]. 2017;19(2):324-331. Available from: https://sid.ir/paper/692524/en

    IEEE: Copy

    REZA FARDID, ASHKAN SALAJEGHEH, MOHAMMAD AMIN MOSLEH SHIRAZI, SEDIGHEH SHARIFZADEH, MOHAMMAD ALI OKHOVAT, MASOUD NAJAFI, ABOLHASAN REZAEYAN, and AKBAR ABASZADEH, “MELATONIN AMELIORATES THE PRODUCTION OF COX-2, INOS, AND THE FORMATION OF 8-OHDG IN NON-TARGETED LUNG TISSUE AFTER PELVIC IRRADIATION (SHORT COMMUNICATION),” CELL JOURNAL (YAKHTEH), vol. 19, no. 2, pp. 324–331, 2017, [Online]. Available: https://sid.ir/paper/692524/en

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