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Information Journal Paper

Title

Bunium persicum essential oil reduced acetic acid-induced rat colitis through suppression of NF-κ B pathway

Pages

  505-514

Abstract

 Objective: The aim of this study was to evaluate the anti-inflammatory effect of B. persicum essential oil on colonic inflammation and the role of suppression of NF-κ B pathway in rat colitis induced by Acetic acid solution. Materials and Methods: Induction of acute colitis was done by intra-luminal instillation of 2 ml of Acetic acid (4%) diluted in normal saline. Two hours after colitis induction, 0. 2% tween 80 in normal saline, prednisolone (4 mg/kg) or B. persicum essential oil (100, 200, and 400 mg/kg) were administered to the rats orally and continued for 5 consecutive days. The severity of macroscopic and microscopic damages was assessed. Myeloperoxidase and TNF-α activity was evaluated by biochemical analysis and ELISA respectively and protein expression of p-NF-κ B was assessed by immunohistochemistry (IHC). Results: Prednisolone and B. persicum essential oil (100, 200, and 400 mg/kg) decreased macroscopic and microscopic injuries compared to the Acetic acid group. On the other hand, prednisolone and B. persicum essential oil (200 and 400 mg/kg) decreased the activity of MPO and TNF-α in the colon tissue of rats compared with the Acetic acid group. Furthermore, they suppressed the expression of p-NF-κ B protein induced by Acetic acid administration. Conclusion: It is suggested that the anti-inflammatory effect of B. persicum essential oil on Acetic acid-induced colitis in rats may be due to the suppression of NF-κ B pathway.

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    Cite

    APA: Copy

    Rashidian, Amir, Akbarzadeh, Dorna, ASGARPANAH, JINOUS, & DEHPOUR, AHMADREZA. (2021). Bunium persicum essential oil reduced acetic acid-induced rat colitis through suppression of NF-κ B pathway. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(5), 505-514. SID. https://sid.ir/paper/692833/en

    Vancouver: Copy

    Rashidian Amir, Akbarzadeh Dorna, ASGARPANAH JINOUS, DEHPOUR AHMADREZA. Bunium persicum essential oil reduced acetic acid-induced rat colitis through suppression of NF-κ B pathway. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(5):505-514. Available from: https://sid.ir/paper/692833/en

    IEEE: Copy

    Amir Rashidian, Dorna Akbarzadeh, JINOUS ASGARPANAH, and AHMADREZA DEHPOUR, “Bunium persicum essential oil reduced acetic acid-induced rat colitis through suppression of NF-κ B pathway,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 5, pp. 505–514, 2021, [Online]. Available: https://sid.ir/paper/692833/en

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