EFFECT OF BENZALKONIUM CHLORIDE ON BIOFILM OF BACTERIA CAUSING NOSOCOMIAL INFECTIONS

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EBRAHIMI KAHRIZSANGI AZIZ ALAH; HABIBIAN DEHKORDI SAEED; SHABANPOUR ZIBA; HAKIMI ALNI REZA; HEMATI MAJID

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Journal: MEDICAL LABORATORY JOURNAL Year:2016 | Volume:10 | Issue:6 Page(s): 14-20

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Title

EFFECT OF BENZALKONIUM CHLORIDE ON BIOFILM OF BACTERIA CAUSING NOSOCOMIAL INFECTIONS

Author(s)

Keywords

BIOFILM

BENZALKONIUM CHLORIDE

PSEUDOMONAS AERUGINOSA

STAPHYLOCOCCUS AUREUS

ENTEROBACTER

ACINETOBACTER

Abstract

Background and Objective: BIOFILMs are community of bacteria that attach to inanimate surfaces or living tissues via production of extracellular polymers and exopolysaccharide matrix. Microbial BIOFILMs on various surfaces of the hospital environment are considered as a reservoir of infection spread. The present study aimed to evaluate the disinfecting effect of BENZALKONIUM CHLORIDE on some bacterial isolates causing nosocomial infections.Methods: First, 13 isolates from four bacteria including PSEUDOMONAS AERUGINOSA, STAPHYLOCOCCUS AUREUS, ACINETOBACTERand ENTEROBACTER were obtained from Microbiology Laboratory of Al-Zahra Hospital in Isfahan, Iran. The samples were transferred to Microbiology Laboratory of Faculty of Veterinary Medicine of Shahrekord University for testing. Evaluation of BIOFILM formation and determination of minimum inhibitory concentration (MIC) of the disinfectant and effect of the disinfectant on planktonic growth and BIOFILM formation were performed.Results: All bacterial isolates (52 cases) produced BIOFILM. Mean MIC of BENZALKONIUM CHLORIDE forP. aeruginosa, S. aureus, ENTEROBACTER and ACINETOBACTER was 0.14, 0.2, 0.18, 0.17 g/ml, respectively. Planktonic growth of all four bacteria was inhibited at concentrations of 2MIC, MIC and 1/2MIC. BIOFILM was not produced in MIC and 2MIC concentrations, and BIOFILM formation capability increased by reducing the concentration of BENZALKONIUM CHLORIDE.Conclusion: The results show that the use of appropriate concentration of BENZALKONIUM CHLORIDE can prevent the growth of different bacterial species, but sub-MIC dose of this disinfectant may stimulate BIOFILM formation.

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APA: Copy

EBRAHIMI KAHRIZSANGI, AZIZ ALAH, HABIBIAN DEHKORDI, SAEED, SHABANPOUR, ZIBA, HAKIMI ALNI, REZA, & HEMATI, MAJID. (2016). EFFECT OF BENZALKONIUM CHLORIDE ON BIOFILM OF BACTERIA CAUSING NOSOCOMIAL INFECTIONS. MEDICAL LABORATORY JOURNAL, 10(6), 14-20. SID. https://sid.ir/paper/692981/en

Vancouver: Copy

EBRAHIMI KAHRIZSANGI AZIZ ALAH, HABIBIAN DEHKORDI SAEED, SHABANPOUR ZIBA, HAKIMI ALNI REZA, HEMATI MAJID. EFFECT OF BENZALKONIUM CHLORIDE ON BIOFILM OF BACTERIA CAUSING NOSOCOMIAL INFECTIONS. MEDICAL LABORATORY JOURNAL[Internet]. 2016;10(6):14-20. Available from: https://sid.ir/paper/692981/en

IEEE: Copy

AZIZ ALAH EBRAHIMI KAHRIZSANGI, SAEED HABIBIAN DEHKORDI, ZIBA SHABANPOUR, REZA HAKIMI ALNI, and MAJID HEMATI, “EFFECT OF BENZALKONIUM CHLORIDE ON BIOFILM OF BACTERIA CAUSING NOSOCOMIAL INFECTIONS,” MEDICAL LABORATORY JOURNAL, vol. 10, no. 6, pp. 14–20, 2016, [Online]. Available: https://sid.ir/paper/692981/en

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