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Information Journal Paper

Title

Steroids with and Without Antivirals in the Treatment of Bell's Palsy: Does It Make any Difference in Recovery? A Study at a Tertiary Care Center, Karachi, Pakistan

Pages

  0-0

Abstract

 Objectives: To compare the pharmacological effects of steroids in comparison to steroids with antiviral drugs for the treatment of Bell’ s Palsy. Methods: A total 60 patients were enrolled and segregated equally into two groups, where patients on Prednisolone were labeled as group A (Control group), whereas patients on Prednisolone + Acyclovir were labeled as group B (study group). All patients had House Brackmann score. The control group started oral Prednisolone 1 mg/kg for 10 days, whereas the study group started Acyclovir 400 mg 4 times a day for 10 days along with Prednisolone tablets. Patients were regularly observed till the study was completed. Primary outcome measure was facial nerve recovery. Health-related quality of life and facial appearance were considered secondary outcomes. Results: The primary outcomes assessed as complete recovery from Bell's Palsy by Brackmann score at week 4 were found in 17/30 (57%) patients and 23/30 (77%) patients at week 8 in the control group. Complete recovery from Bell's Palsy was also shown in the experimental group (Prednisolone + Acyclovir) where 25/30 (83%) patients completed recovery at week 4, while 27/30 (90%) patients at week 8. Comparison of the two groups showed a significant improvement in the study group (Prednisolone + Acyclovir) (P = 0. 047) at week 4 and (P = 0. 02) at week 8. The secondary outcomes were assessed as improvement in the quality of life and facial appearance from Bell's Palsy. Health utility score was 0. 84 ± 0. 01 in the control group (On Prednisolone) with facial appearance score of (Derriford Appearance Scale 59) 61 ± 28. At week 4, the study group (on Prednisolone+ Acyclovir) showed 0. 88 ± 0. 12 score on Health utility index scale-3 and 46 ± 26 score on Derriford Appearance Scale. Comparison of the quality of life (Health quality index scale-3) and facial appearance among both control and study groups showed a significant improvement in the study group (P = 0. 001 and P = 0. 005, respectively). Moreover, when health utility score and Derriford appearance were compared among both groups, it showed a significant improvement in the study group (P = 0. 001 and 0. 016, respectively). Conclusions: The combination of Prednisolone with Acyclovir is found superior to Prednisolone alone, and this combination treatment results in improvement in both recovery and quality of life.

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    APA: Copy

    Talib, Abu, Baloch, Gohar, Naqvi, Iftikhar Haider, & Ubaid, Muhammad. (2021). Steroids with and Without Antivirals in the Treatment of Bell's Palsy: Does It Make any Difference in Recovery? A Study at a Tertiary Care Center, Karachi, Pakistan. ARCHIVES OF NEUROSCIENCE, 8(3), 0-0. SID. https://sid.ir/paper/693646/en

    Vancouver: Copy

    Talib Abu, Baloch Gohar, Naqvi Iftikhar Haider, Ubaid Muhammad. Steroids with and Without Antivirals in the Treatment of Bell's Palsy: Does It Make any Difference in Recovery? A Study at a Tertiary Care Center, Karachi, Pakistan. ARCHIVES OF NEUROSCIENCE[Internet]. 2021;8(3):0-0. Available from: https://sid.ir/paper/693646/en

    IEEE: Copy

    Abu Talib, Gohar Baloch, Iftikhar Haider Naqvi, and Muhammad Ubaid, “Steroids with and Without Antivirals in the Treatment of Bell's Palsy: Does It Make any Difference in Recovery? A Study at a Tertiary Care Center, Karachi, Pakistan,” ARCHIVES OF NEUROSCIENCE, vol. 8, no. 3, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/693646/en

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