EFFECTS OF CONTINUOUS TRAINING INTENSITY ON AMYLOID BETA1-42 (Aβ1-42) LEVELS IN HIPPOCAMPUS OF HOMOCYSTEINE-INDUCED ALZHEIMER'S MODEL RATS

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YAGHOUBI ALI; SAGHEBJOO MARZIYEH; Fallahmohammadi Zia; HEDAYATI MEHDI; HAJIZADEH MOGHADDAM AKBAR

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:18 | Issue:11 (104) Page(s): 83-93

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Title

EFFECTS OF CONTINUOUS TRAINING INTENSITY ON AMYLOID BETA1-42 (Aβ1-42) LEVELS IN HIPPOCAMPUS OF HOMOCYSTEINE-INDUCED ALZHEIMER'S MODEL RATS

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Keywords

ALZHEIMERQ1

HIGH INTENSITY CONTINUOUS TRAININGQ2

LOW INTENSITY CONTINUOUS TRAININGQ2

AMYLOID BETA PROTEIN 1-42Q2

HIPPOCAMPUSQ1

Abstract

Background: The Amyloid beta (Ab) level increases in the brain of patients with ALZHEIMER's disease. The present study aimed to investigate the effects of eight weeks continuous training with low and high intensities on Ab1-42 levels in HIPPOCAMPUS of ALZHEIMER model rats.Materials and Methods: Fifty male Wistar rats (12 weeks old and mean weight 219.82±13.10 g) were divided into five groups including: healthy control, ALZHEIMER’s control, ALZHEIMER's lowintensity training, ALZHEIMER's high-intensity training and sham. To induce ALZHEIMER's disease, homocysteine is infused into the rats cerebroventricular (dose of 0.6M). Low intensity groups trained with 20m/min (50-55% VO2max) and high-intensity groups trained with 27m/min (75-80% VO2max), 60min/day, and five days per week on the treadmill. For data analysis, one-way ANOVA and post hoc Tukey test were performed (p<0.05).Results: The Ab1-42 levels in HIPPOCAMPUS of ALZHEIMER's control group was significantly higher than healthy control group (p=0.001) and in training groups with both low and high intensity was significantly lower than ALZHEIMER's control group (p=0.02). But no significant differences were found between two intensity (p=0.99).Conclusion: It seems that continuous exercise training, through reducing the level of Ab1-42 in HIPPOCAMPUS, can be useful for ALZHEIMER’s disease model rats and continuous training can be tudied as a complementary therapy in ALZHEIMER's disease.

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APA: Copy

YAGHOUBI, ALI, SAGHEBJOO, MARZIYEH, Fallahmohammadi, Zia, HEDAYATI, MEHDI, & HAJIZADEH MOGHADDAM, AKBAR. (2016). EFFECTS OF CONTINUOUS TRAINING INTENSITY ON AMYLOID BETA1-42 (Aβ_1-42) LEVELS IN HIPPOCAMPUS OF HOMOCYSTEINE-INDUCED ALZHEIMER'S MODEL RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 18(11 (104)), 83-93. SID. https://sid.ir/paper/69410/en

Vancouver: Copy

YAGHOUBI ALI, SAGHEBJOO MARZIYEH, Fallahmohammadi Zia, HEDAYATI MEHDI, HAJIZADEH MOGHADDAM AKBAR. EFFECTS OF CONTINUOUS TRAINING INTENSITY ON AMYLOID BETA1-42 (Aβ_1-42) LEVELS IN HIPPOCAMPUS OF HOMOCYSTEINE-INDUCED ALZHEIMER'S MODEL RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;18(11 (104)):83-93. Available from: https://sid.ir/paper/69410/en

IEEE: Copy

ALI YAGHOUBI, MARZIYEH SAGHEBJOO, Zia Fallahmohammadi, MEHDI HEDAYATI, and AKBAR HAJIZADEH MOGHADDAM, “EFFECTS OF CONTINUOUS TRAINING INTENSITY ON AMYLOID BETA1-42 (Aβ_1-42) LEVELS IN HIPPOCAMPUS OF HOMOCYSTEINE-INDUCED ALZHEIMER'S MODEL RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 18, no. 11 (104), pp. 83–93, 2016, [Online]. Available: https://sid.ir/paper/69410/en

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