ANTINOCICEPTIVE EFFECT OF OLIVE OIL (OLEA EUROPAEA L.) ON MICE

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EIDI A.; MOGHADAM KIA S.; ZARRINGHALAM MOGHADAM J.; REZAZADEH S.; EIDI M.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2011 | Volume:14 | Issue:4 (57) Page(s): 52-59

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Title

ANTINOCICEPTIVE EFFECT OF OLIVE OIL (OLEA EUROPAEA L.) ON MICE

Author(s)

Keywords

ANTINOCICEPTIVEQ2

FORMALIN TESTQ2

MOUSEQ2

OLIVE (OLEA EUROPAEA L.)Q2

WRITHING TESTQ2

Abstract

Background: In traditional medicine, Olive oil (Olea europaea L.) from Oleaceae family is known as a remedy for alleviating pain. This study investigates the ANTINOCICEPTIVE effects of olive oil on male adult NMRI mice.Materials and Methods: In this experimental study, using the acetic acid-induced writhing and FORMALIN TESTs, the anticipative effects of olive oil were evaluated. Olive oil (1, 5, and 10 ml/kg bodyweight), morphine (10 mg/kg bodyweight), and indomethacin (10 mg/kg bodyweight), as standard drugs, were injected intraperitoneally. The control group did not receive any treatment. Data were analyzed using one-way ANOVA and Tukey test.Results: Olive oil significantly decreased acetic acid-induced abdominal writhes (P<0.001). Olive oil could only decrease the induced pain in the second phase of the FORMALIN TEST (P<0.001).Conclusion: Olive oil decreases inflammatory pain (the second phase of the FORMALIN TEST and acetic acid-induced WRITHING TESTs), but it has no significant effects on neurogenic pain (the first phase of the FORMALIN TEST). Further studies are required to elucidate the ANTINOCICEPTIVE effects of olive oil.

Cites

EFFECT OF DIETARY VIRGIN OLIVE (OLEA EUROPAEA) OIL ON NOCICEPTION AND ITS EFFECT ON MORPHINE-INDUCED ANALGESIA IN MALE MICE USING FORMALIN TEST

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APA: Copy

EIDI, A., MOGHADAM KIA, S., ZARRINGHALAM MOGHADAM, J., REZAZADEH, S., & EIDI, M.. (2011). ANTINOCICEPTIVE EFFECT OF OLIVE OIL (OLEA EUROPAEA L.) ON MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 14(4 (57)), 52-59. SID. https://sid.ir/paper/69457/en

Vancouver: Copy

EIDI A., MOGHADAM KIA S., ZARRINGHALAM MOGHADAM J., REZAZADEH S., EIDI M.. ANTINOCICEPTIVE EFFECT OF OLIVE OIL (OLEA EUROPAEA L.) ON MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2011;14(4 (57)):52-59. Available from: https://sid.ir/paper/69457/en

IEEE: Copy

A. EIDI, S. MOGHADAM KIA, J. ZARRINGHALAM MOGHADAM, S. REZAZADEH, and M. EIDI, “ANTINOCICEPTIVE EFFECT OF OLIVE OIL (OLEA EUROPAEA L.) ON MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 14, no. 4 (57), pp. 52–59, 2011, [Online]. Available: https://sid.ir/paper/69457/en

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