The Anti-inflammatory and Antioxidative Effects of Selenium Supplementation on Critical Post-surgical Pediatric Patients

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Roudi Fatemeh; Zakerian Mohsen; Ranjbar Golnaz

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Journal of Nutrition, Fasting and Health Year:2020 | Volume:8 | Issue:2 Page(s): 75-79

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Information Journal Paper

Title

The Anti-inflammatory and Antioxidative Effects of Selenium Supplementation on Critical Post-surgical Pediatric Patients

Author(s)

Roudi Fatemeh | Zakerian Mohsen | Ranjbar Golnaz | Issue Writer Certificate

Keywords

Selenium

Surgical Procedures

Operative

Inflammation

Oxidative Stress

Abstract

Oxidative Stress after major surgeries is associated with poor clinical outcomes, such as delayed wound healing and increased length of stay in the pediatric intensive care unit. Due to the growth and development phase in childhood, changes in the levels of Oxidative Stress and Inflammation are of paramount importance in pediatric patients. Acute metabolic stress is correlated with the rate of Oxidative Stress and is believed to increase after major surgeries in pediatric patients. Therefore, it has been suggested that the presence of Selenium in various selenoenzymes and selenoproteins may be largely involved in the antioxidative defense system in surgical Inflammation through the regulation of glycolysis, gluconeogenesis, insulin transport pathways, gene expression of inflammatory mediators, and other functions of lymphocytes B and T, natural killer, and lymphokine activated killer cells. In acute metabolic stress, Selenium requirement following major surgeries is considered essential in pediatric patients, and Selenium supplementation in these patients may be helpful and cost-effective in the long run. Further clinical studies are required to clarify the potential beneficial effects of Selenium supplementation, as well as its dose safety and efficacy rate.

Cites

The Effects of High-dose Selenium Supplementation on the Oxidative Stress Status and Inflammatory Markers in Critically Ill Pediatric Patients after Gastrointestinal Surgery: A Randomized Clinical Trial Protocol Study

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APA: Copy

Roudi, Fatemeh, Zakerian, Mohsen, & Ranjbar, Golnaz. (2020). The Anti-inflammatory and Antioxidative Effects of Selenium Supplementation on Critical Post-surgical Pediatric Patients. JOURNAL OF NUTRITION, FASTING AND HEALTH, 8(2), 75-79. SID. https://sid.ir/paper/694739/en

Vancouver: Copy

Roudi Fatemeh, Zakerian Mohsen, Ranjbar Golnaz. The Anti-inflammatory and Antioxidative Effects of Selenium Supplementation on Critical Post-surgical Pediatric Patients. JOURNAL OF NUTRITION, FASTING AND HEALTH[Internet]. 2020;8(2):75-79. Available from: https://sid.ir/paper/694739/en

IEEE: Copy

Fatemeh Roudi, Mohsen Zakerian, and Golnaz Ranjbar, “The Anti-inflammatory and Antioxidative Effects of Selenium Supplementation on Critical Post-surgical Pediatric Patients,” JOURNAL OF NUTRITION, FASTING AND HEALTH, vol. 8, no. 2, pp. 75–79, 2020, [Online]. Available: https://sid.ir/paper/694739/en

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