مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

80
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

48
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Down-regulation of insulin substrate receptor 1 and 2 in the liver may be a mechanism for insulin resistance during testosterone deprivation

Pages

  33-40

Abstract

 Background and Objective: Type 2 Diabetes is a global concern worldwide. Despite extensive studies on the physiological effects of Diabetes on the testicular functions, the impact of testosterone deficiency on the glucose homeostasis remains to be clarified. This study was designed to investigate the effects of testosterone deprivation and its replacement with testosterone enanthate on the molecular mechanisms of insulin signaling pathway in the liver of rats. Materials and Methods: We first established a rat model of testosterone deficiency by castration (CAS-S). Subsequently, the castrated rats were administrated by subcutaneous injection of testosterone (CAS-T). Thereafter, fasting blood glucose (FBG), insulin, and homeostasis model-insulin resistance (HOMA-IR) level was assessed. The testosterone and insulin levels were further analyzed by ELISA. The mRNA expression of insulin receptor (IR)-β , insulin receptor-substrate (IRS)1 and 2 as well as glucose transporter (GLUT) 2 in the liver was analyzed by q-RT-PCR assay. Results: Our data showed that testosterone deprivation significantly increases FBG and HOMA-IR and down-regulates IRS-1 and IRS-2 mRNA expression in the liver. However, the mRNA expression of GLUT2 and IR-β was not affected. We also found that testosterone administration could improve the liver insulin resistance. Conclusion: These findings suggested that testosterone deprivation can impact insulin signaling in the liver via suppressing expression of IRS-1 and IRS-2 mRNA and treatment with testosterone can improve the insulin resistance in the castrated rats. Further experimental and clinical pathways are needed to be assessed for clinical application of our finding.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    GHOWSI, MAHNAZ, & SISAKHTNEZHAD, SAJJAD. (2021). Down-regulation of insulin substrate receptor 1 and 2 in the liver may be a mechanism for insulin resistance during testosterone deprivation. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, 9(1), 33-40. SID. https://sid.ir/paper/694812/en

    Vancouver: Copy

    GHOWSI MAHNAZ, SISAKHTNEZHAD SAJJAD. Down-regulation of insulin substrate receptor 1 and 2 in the liver may be a mechanism for insulin resistance during testosterone deprivation. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY[Internet]. 2021;9(1):33-40. Available from: https://sid.ir/paper/694812/en

    IEEE: Copy

    MAHNAZ GHOWSI, and SAJJAD SISAKHTNEZHAD, “Down-regulation of insulin substrate receptor 1 and 2 in the liver may be a mechanism for insulin resistance during testosterone deprivation,” JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, vol. 9, no. 1, pp. 33–40, 2021, [Online]. Available: https://sid.ir/paper/694812/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button