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Information Journal Paper

Title

EVALUATION OF THE EFFECT OF COMBINATION OF N-ACETYLCYSTEINE AND VITAMIN C ON IMPROVING OUTCOMES FOLLOWING CABG

Pages

  29-39

Abstract

 Background: Post ischemic myocardial reperfusion can impair CABG outcomes and cause increased mortality, hospital stay and costs. Then, increased oxygen free radicals lead to lipid peroxidation and sulfhydryl group oxidation. The aim of this study is to evaluate whether Nacetylcysteine and VITAMIN C as antioxidants could effect postoperative outcomes of on-pump CABG.Materials and Methods: In this clinical trial, patients who had undergone CABG were studied in 4 groups receiving VITAMIN C, N-acetylcysteine, VITAMIN C & N- ACETYLCYSTEINE and traditional drugs. The study population consisted of 50 patients in each group. Data were recorded in a checklist and analyzed by using SPSS 20.Results: Mean pump time, ICU stay, hospital stay, the distribution of troponin positive serum, arrhythmia and need for reoperation were significantly different between groups. Gender distribution, mean cross-clamp time, serum creatinine level before and after surgery, the need for inotropic drugs and required dose level of it, showed no significant differences between groups.Conclusion: It seems that the combination of N-acetylcysteine and VITAMIN C had a stronger effect on the defference between the mean of pump time, hospital length stay and length of ICU stay versus the administration of N-acetylcysteine or VITAMIN C alone.

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    APA: Copy

    ROSTAMI, ALI REZA, SHARIFI, MEHRZAD, KAMALI, ALI REZA, & KALANTARI, MASOOMEH. (2016). EVALUATION OF THE EFFECT OF COMBINATION OF N-ACETYLCYSTEINE AND VITAMIN C ON IMPROVING OUTCOMES FOLLOWING CABG. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 18(10 (103)), 29-39. SID. https://sid.ir/paper/69485/en

    Vancouver: Copy

    ROSTAMI ALI REZA, SHARIFI MEHRZAD, KAMALI ALI REZA, KALANTARI MASOOMEH. EVALUATION OF THE EFFECT OF COMBINATION OF N-ACETYLCYSTEINE AND VITAMIN C ON IMPROVING OUTCOMES FOLLOWING CABG. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;18(10 (103)):29-39. Available from: https://sid.ir/paper/69485/en

    IEEE: Copy

    ALI REZA ROSTAMI, MEHRZAD SHARIFI, ALI REZA KAMALI, and MASOOMEH KALANTARI, “EVALUATION OF THE EFFECT OF COMBINATION OF N-ACETYLCYSTEINE AND VITAMIN C ON IMPROVING OUTCOMES FOLLOWING CABG,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 18, no. 10 (103), pp. 29–39, 2016, [Online]. Available: https://sid.ir/paper/69485/en

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