COMPARING THE EFFECT OF NEURONAL TYPE NA+CHANNEL BLOCK ON PACEMAKER ACTIVITY OF C57BL6/J MOUSE SINOATRIAL AND ATRIOVETRICULAR NODE

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NIKMARAM M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: Journal of Arak University Medical Sciences Year:2008 | Volume:10 | Issue:4 (41) Page(s): 74-80

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Title

COMPARING THE EFFECT OF NEURONAL TYPE NA+CHANNEL BLOCK ON PACEMAKER ACTIVITY OF C57BL6/J MOUSE SINOATRIAL AND ATRIOVETRICULAR NODE

Author(s)

NIKMARAM M.R. | Issue Writer Certificate

Keywords

SINOATRIAL NODEQ3

ATRIOVENTRICULAR NODEQ3

CYCLE LENGTHQ3

NEURONAL TYPE NA+ CHANNELQ3

TTXQ3

Abstract

Introduction: In resent years, neuronal type Na+ channel is one of the important currents for action potential depolarization phase in heart cells. In this study neuronal type Na+ channel is blocked by low concentration of TTX to compare the effect of TTX blocker on pacemaker activity of SINOATRIAL NODE (SAN) and ATRIOVENTRICULAR NODE (AVN) of mouse heart.Materials and Methods: In this experimental study the pacemaker activity of distinct intact SAN and AVN, was recorded before and during consuming 100 nM TTX and CYCLE LENGTH (CL) was measured. Data was analyzed using T test.Results: 100 nM TTX increased CL on SAN preparations by 22.2±6% and on AVN preparations by 52.5±13.5%. These changes were significant in the two nodes.Conclusion: It is possible to conclude that; the neuronal type Na+ channel was present in the two nodes, and the effect of TTX on CL of the two nodes was different.

Cites

NEUROTOXIC SYNDROMES IN MARINE POISONINGS; A REVIEW

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APA: Copy

NIKMARAM, M.R.. (2008). COMPARING THE EFFECT OF NEURONAL TYPE NA+CHANNEL BLOCK ON PACEMAKER ACTIVITY OF C57BL6/J MOUSE SINOATRIAL AND ATRIOVETRICULAR NODE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 10(4 (41)), 74-80. SID. https://sid.ir/paper/69496/en

Vancouver: Copy

NIKMARAM M.R.. COMPARING THE EFFECT OF NEURONAL TYPE NA+CHANNEL BLOCK ON PACEMAKER ACTIVITY OF C57BL6/J MOUSE SINOATRIAL AND ATRIOVETRICULAR NODE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2008;10(4 (41)):74-80. Available from: https://sid.ir/paper/69496/en

IEEE: Copy

M.R. NIKMARAM, “COMPARING THE EFFECT OF NEURONAL TYPE NA+CHANNEL BLOCK ON PACEMAKER ACTIVITY OF C57BL6/J MOUSE SINOATRIAL AND ATRIOVETRICULAR NODE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 10, no. 4 (41), pp. 74–80, 2008, [Online]. Available: https://sid.ir/paper/69496/en

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