Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’ s formalin test

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Hashemi Mahboobeh; KARAMI MANIZHEH; Zarrindast Mohammadreza

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Basic and Clinical Pathophysiology Year:2021 | Volume:9 | Issue:1 Page(s): 58-62

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’ s formalin test

Author(s)

Hashemi Mahboobeh | KARAMI MANIZHEH | Zarrindast Mohammadreza | Issue Writer Certificate

Keywords

L-arginine

PAG

Hippocampus

Formalin test

Abstract

Background and Objective: Injection of PAGe=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">L-arginine, a precursor of nitric oxide, in the rat’ s Hippocampus or periaqueductal gray matter reduces the analgesic effect of morphine on formalin-induced pain, but the effect of simultaneous injection of the substance in both areas have not been shown as our purpose of this research. Materials and Methods: Wistar rats were used as control, morphine, and PAGe=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">L-arginine groups. The rats were simultaneously cannulated in two areas of the dorsal Hippocampus and laterodorsal PAG. One week later, the control animals received 50 μ l of 2. 5% formalin in the paw of the left foot under restrainer. The morphine group 10 min before formalin received the opioid (6 mg/kg, intraperitoneally). Other groups took PAGe=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">L-arginine (0. 25-2 μ g/rat) in only one area (d Hippocampus or ld PAG), prior to morphine administration. The effective dose of PAGe=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">L-arginine (0. 5 μ g/rat) simultaneously was injected in both areas. The findings were analyzed by analysis of variance (ANOVA) under α =0. 05. Results: Morphine induced analgesic response. Injection of NO precursor both separately and simultaneously in the two nuclei reduced morphine-induced analgesia. Conclusion: Increasing levels of NO due to exclusive or concurrent injection of PAGe=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">L-arginine in the areas likely antagonize the morphine response.

Cites

No record.

References

No record.

Cite

APA: Copy

Hashemi, Mahboobeh, KARAMI, MANIZHEH, & Zarrindast, Mohammadreza. (2021). Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’ s formalin test. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, 9(1), 58-62. SID. https://sid.ir/paper/695350/en

Vancouver: Copy

Hashemi Mahboobeh, KARAMI MANIZHEH, Zarrindast Mohammadreza. Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’ s formalin test. JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY[Internet]. 2021;9(1):58-62. Available from: https://sid.ir/paper/695350/en

IEEE: Copy

Mahboobeh Hashemi, MANIZHEH KARAMI, and Mohammadreza Zarrindast, “Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’ s formalin test,” JOURNAL OF BASIC & CLINICAL PATHOPHYSIOLOGY, vol. 9, no. 1, pp. 58–62, 2021, [Online]. Available: https://sid.ir/paper/695350/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops