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Information Journal Paper

Title

Correlation between the Expression Levels of Circulating miR-21 and miR-192 and Clinicopathological Features in Plasma of Patients with Gastric Cancer in Iran

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Abstract

 Background: Gastric cancer (GC) is the most prevalent malignancy worldwide and a common cause of death in Iran. Studies have proved that a variety of dysregulated microRNAs is involved in the development and progression of Gastric cancer. The present study aimed to evaluate the expression levels of plasma circulating oncogenic miR-21 and miR-192 and their association with clinical phenotypes of patients with Gastric cancer in the north of Iran. Methods: Clinico-pathological analysis was conducted using a standard protocol and pathological tests. The expression levels of miR-21 and miR-192 were measured using quantitative reverse transcription-polymerase chain reaction in the plasma of twenty pre/post-operative Gastric cancer patients and twenty healthy subjects. The receiver operating characteristic (ROC) curve of these microRNAs was analyzed to investigate their diagnosis properties. Results: The study results indicated that plasma miR-21 expression was significantly associated with tumor stage and helicobacter pylori infection status (P=0. 024, P=0. 0004, respectively). However, no association was observed between clinic-pathological characteristics and miR-192 expression. The results showed that the plasma levels of miR-21 (P=0. 0001) and miR-192 (P=0. 0007) were significantly higher in GC patients compared to those in healthy individuals. Furthermore, the ROC analyses yielded the mean ± SD area under the curve (AUC) values of 0. 9525± 0. 03 (P<0. 0001) and 0. 5925± 0. 09 (P=0. 316) for miR-21 and miR-192, respectively. Pearson regression analysis showed that there was no significant correlation between the expression of miR-21 and miR-192 (P=0. 1507). Conclusion: Based on the obtained results, the expression of the plasma level of miR-21 was significantly higher in Gastric cancer patients compared to that in the healthy group. Furthermore, the higher levels of AUC in miR-21 indicated the potential role of miR-21 as a noninvasive biomarker for the prognosis of Gastric cancer in the population of the north of Iran.

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    APA: Copy

    Asadi Rahmani, Fatemeh, RANJI, NAJMEH, & SAEIDI SAEDI, HAMID. (2021). Correlation between the Expression Levels of Circulating miR-21 and miR-192 and Clinicopathological Features in Plasma of Patients with Gastric Cancer in Iran. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 23(6), 0-0. SID. https://sid.ir/paper/695412/en

    Vancouver: Copy

    Asadi Rahmani Fatemeh, RANJI NAJMEH, SAEIDI SAEDI HAMID. Correlation between the Expression Levels of Circulating miR-21 and miR-192 and Clinicopathological Features in Plasma of Patients with Gastric Cancer in Iran. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2021;23(6):0-0. Available from: https://sid.ir/paper/695412/en

    IEEE: Copy

    Fatemeh Asadi Rahmani, NAJMEH RANJI, and HAMID SAEIDI SAEDI, “Correlation between the Expression Levels of Circulating miR-21 and miR-192 and Clinicopathological Features in Plasma of Patients with Gastric Cancer in Iran,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 23, no. 6, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/695412/en

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