Cardioprotective Role of Myocardial Endothelial Nitric Oxide Synthase and Serum Nitric Oxide Induced by Hexarelin in Rats with Myocardial Infarction-Induced Heart Failure

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Agbo Elvis; Liu Donghai; Liao Jiawan; Saahene Roland Osei; Barnes Precious

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Journal: Iranian Red Crescent Medical Journal Year:2021 | Volume:23 | Issue:6 Page(s): 0-0

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Title

Cardioprotective Role of Myocardial Endothelial Nitric Oxide Synthase and Serum Nitric Oxide Induced by Hexarelin in Rats with Myocardial Infarction-Induced Heart Failure

Author(s)

Keywords

Apoptosis

Heart failure

Hexarelin

eNOS

Myocardial infarction

Nitric oxide

Abstract

Background: Growth hormone-releasing peptides (GHRP) have been reported to possess cardioprotective properties; nonetheless, their mechanisms of action are still not very clear. Objectives: Some studies have suggested that modulation of endothelial Nitric oxide synthase (eNOS) and the upregulation of Nitric oxide (NO) are cardioprotective. Therefore, the present study strived to test the hypothesis that a potent GHRP analog (Hexarelin) could increase serum Nitric oxide level and regulate myocardial eNOS to alleviate the development of Heart failure. Methods: Myocardial infarction-induced Heart failure in rats was established by permanent coronary artery ligation. The sham group, control group, and Heart failure group all received normal saline (100 μ g/kg; SC BID; 30days), while the rats in the Hexarelin treatment group were treated with Hexarelin (100 μ g/kg, SC BID, 30 days). The rats were tested for myocardial Apoptosis, oxidative stress, left ventricular function, various molecular analyses, as well as pathological and structural myocardial changes. Results: Hexarelin treatment improved contractile function and attenuated myocardial histopathological damages, oxidative stress, fibrosis, as well as Apoptosis. All these were accompanied by the upregulation of myocardial eNOS and an increase in serum NO concentration. Conclusion: As evidenced by the obtained results, the anti-cardiac failure capacity of Hexarelin in a rat model is mediated by an increase in serum Nitric oxide level and the up-modulation of myocardial eNOS; therefore, they can be considered therapeutic targets against Heart failure.

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References

Hexarelin protects cardiac H9C2 cells from angiotensin II-induced hypertrophy via the regulation of autophagy

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APA: Copy

Agbo, Elvis, Liu, Donghai, Liao, Jiawan, Saahene, Roland Osei, & Barnes, Precious. (2021). Cardioprotective Role of Myocardial Endothelial Nitric Oxide Synthase and Serum Nitric Oxide Induced by Hexarelin in Rats with Myocardial Infarction-Induced Heart Failure. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 23(6), 0-0. SID. https://sid.ir/paper/695417/en

Vancouver: Copy

Agbo Elvis, Liu Donghai, Liao Jiawan, Saahene Roland Osei, Barnes Precious. Cardioprotective Role of Myocardial Endothelial Nitric Oxide Synthase and Serum Nitric Oxide Induced by Hexarelin in Rats with Myocardial Infarction-Induced Heart Failure. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2021;23(6):0-0. Available from: https://sid.ir/paper/695417/en

IEEE: Copy

Elvis Agbo, Donghai Liu, Jiawan Liao, Roland Osei Saahene, and Precious Barnes, “Cardioprotective Role of Myocardial Endothelial Nitric Oxide Synthase and Serum Nitric Oxide Induced by Hexarelin in Rats with Myocardial Infarction-Induced Heart Failure,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 23, no. 6, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/695417/en

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