SURVEY OF DAOA GENE POLYMORPHISM IN SCHIZOPHRENIC PATIENTS IN IRAN

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Haghighat Shadi; ZAHMATKESH ROODSARI RASOUL; RANJBAR REZA

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Journal Paper

Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2017 | Volume:20 | Issue:4 (121) Page(s): 20-28

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Information Journal Paper

Title

SURVEY OF DAOA GENE POLYMORPHISM IN SCHIZOPHRENIC PATIENTS IN IRAN

Author(s)

Haghighat Shadi | ZAHMATKESH ROODSARI RASOUL | RANJBAR REZA | Issue Writer Certificate

Keywords

D-AMINO ACID OXIDASEQ2

DAOAQ1

NMDAQ1

SCHIZOPHRENIAQ1

Abstract

Background: SCHIZOPHRENIA is a common mentaly disorder with high heritability and variable phenotype that they are placed in bipolar nervous disease family. Different genes are associated with this disease that among of them, DAOA gene plays a significant role. DAOA gene is located in the long arm of chromosome 13 and produces a protein called D-AMINO ACID OXIDASE which is N- metyle D- aspartate (NMDA) receptor activator in the brain. The aim of this study was to investigate the association between DAOA gene polymorphisms and the risk of SCHIZOPHRENIA in Iranian population.Materials and Methods: In this study, 100 patients with SCHIZOPHRENIA and 100 normal people as a control group were investigated. After genomic DNA extraction from blood samples, allele and genotype frequencies in patients and control group were determined by PCR-RFLP method. Data analysis was performed with Med Calc (ver 12) software.Results: Frequency of GG, GA, AA genotypes in patients group was 18%, 42%, 40% and in normal group was 14%, 45%, and 41%, respectively. Statistical analysis revealed that there is a significant relationship between DAOA gene polymorphism with SCHIZOPHRENIA disease in the people under the age of 40.Conclusion: According to the results of this study, the DAOA gene has significant association with SCHIZOPHRENIA in the Iranian population.

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References

GENETIC OVERLAP BETWEEN AFFECTIVE DISORDERS: AN ASSOCIATION ANALYSIS OF M18 AND M23 SNPS OF DAOA/G72 GENE WITH SCHIZOPHRENIA AND BIPOLAR DISORDER

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APA: Copy

Haghighat, Shadi, ZAHMATKESH ROODSARI, RASOUL, & RANJBAR, REZA. (2017). SURVEY OF DAOA GENE POLYMORPHISM IN SCHIZOPHRENIC PATIENTS IN IRAN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(4 (121)), 20-28. SID. https://sid.ir/paper/69557/en

Vancouver: Copy

Haghighat Shadi, ZAHMATKESH ROODSARI RASOUL, RANJBAR REZA. SURVEY OF DAOA GENE POLYMORPHISM IN SCHIZOPHRENIC PATIENTS IN IRAN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(4 (121)):20-28. Available from: https://sid.ir/paper/69557/en

IEEE: Copy

Shadi Haghighat, RASOUL ZAHMATKESH ROODSARI, and REZA RANJBAR, “SURVEY OF DAOA GENE POLYMORPHISM IN SCHIZOPHRENIC PATIENTS IN IRAN,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 4 (121), pp. 20–28, 2017, [Online]. Available: https://sid.ir/paper/69557/en

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