EFFECT OF ACUTE AND CHRONIC ADMINISTRATION OF METHIMAZOLE ON MORPHINE WITHDRAWAL SIGNS IN ADULT MALE MICE

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KESMATI MAHNAZ

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Journal Paper

Paper Information

Journal: Zahedan Journal of Research in Medical Sciences Year:2015 | Volume:17 | Issue:2 Page(s): 0-0

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Information Journal Paper

Title

EFFECT OF ACUTE AND CHRONIC ADMINISTRATION OF METHIMAZOLE ON MORPHINE WITHDRAWAL SIGNS IN ADULT MALE MICE

Author(s)

KESMATI MAHNAZ | Issue Writer Certificate

Keywords

MTZ

MORPHINE WITHDRAWAL

SYNDROME

OPIOID RECEPTORS

Abstract

Background: OPIOID RECEPTORS change in CNS by anti thyroid hormones drugs. In thisstudy effect of acute and chronic methimazole (aMTZ and cMTZ) administration onmorphine withdrawal were investigated.Materials and Methods: In this experimental study adult male mice divided into controland experimental groups receiving aMTZ or cMTZ. All groups were addicted to morphineand MORPHINE WITHDRAWAL was induced by naloxone and jumping, rearing and climbingsigns were evaluated.Results: Acute MTZ and chronic MTZ increased the climbing and jumping (p<0.01, p<0.001). cMTZ was more potent than the acute one.Conclusion: MTZ probably influences an opioid abstinence directly and/or indirectlythrough decrement of thyroid hormones.

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APA: Copy

KESMATI, MAHNAZ. (2015). EFFECT OF ACUTE AND CHRONIC ADMINISTRATION OF METHIMAZOLE ON MORPHINE WITHDRAWAL SIGNS IN ADULT MALE MICE. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 17(2), 0-0. SID. https://sid.ir/paper/695767/en

Vancouver: Copy

KESMATI MAHNAZ. EFFECT OF ACUTE AND CHRONIC ADMINISTRATION OF METHIMAZOLE ON MORPHINE WITHDRAWAL SIGNS IN ADULT MALE MICE. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2015;17(2):0-0. Available from: https://sid.ir/paper/695767/en

IEEE: Copy

MAHNAZ KESMATI, “EFFECT OF ACUTE AND CHRONIC ADMINISTRATION OF METHIMAZOLE ON MORPHINE WITHDRAWAL SIGNS IN ADULT MALE MICE,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 17, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/695767/en

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