THE CARDIOPROTECTIVE EFFECT OF VANILLIC ACID ON HEMODYNAMIC PARAMETERS, MALONDIALDEHYDE, AND INFARCT SIZE IN ISCHEMIA-REPERFUSION ISOLATED RAT HEART EXPOSED TO PM10

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Radmanesh Esmat; DIANAT MAHIN; BADAVI MOHAMMAD; GOUDARZI GHOLAMREZA; MARD SEYYED ALI

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:7 Page(s): 761-769

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Title

THE CARDIOPROTECTIVE EFFECT OF VANILLIC ACID ON HEMODYNAMIC PARAMETERS, MALONDIALDEHYDE, AND INFARCT SIZE IN ISCHEMIA-REPERFUSION ISOLATED RAT HEART EXPOSED TO PM10

Author(s)

Keywords

HEMODYNAMIC PARAMETERS

INFARCT SIZE

ISCHEMIA–REPERFUSION

MALONDIALDEHYDE PARTICULATE MATTER

VANILLIC-ACID

Abstract

Objective(s): Particulate matter (PM) exposure can promote cardiac ischemia and myocardial damage. The effects of PM10 on HEMODYNAMIC PARAMETERS, lipid peroxidation, and INFARCT SIZE induced by ischemia-reperfusion injury and the protective effects of vanillic acid (VA) in isolated rat heart were investigated.Materials and Methods: Eighty male Wistar rats (250–300 g) were divided into 8 groups (n=10): Control, Sham, VAc, VA, PMa (0.5 mg/kg PM, intratracheal instillation), PMb (2.5 mg/kg PM, intratracheal instillation), PMc (5 mg/kg PM, intratracheal instillation), and PMc+VA (5 mg/kg PM, intratracheal instillation; and 10 mg/kg vanillic acid, gavage for 10 days). PM10 was instilled into the trachea in two stages, within 48 hr. After isolating the hearts and transfer to a Langendorff apparatus, hearts were subjected to 30 min ischemia and 60 min reperfusion. HEMODYNAMIC PARAMETERS (±dp/dt, LVSP, LVDP, and RPP), production of lipid peroxidation (MDA), and INFARCT SIZE were assessed.Results: A significant decrease in ±dp/dt, LVSP, LVDP and RPP occurred in PM groups. A significant increase in MDA and myocardial INFARCT SIZE occurred in PM groups. A significant increase in LVDP, LVSP, ±dp/dt, RPP and decrease in INFARCT SIZE, MDA, and myocardial dysfunction was observed in groups that received vanillic acid after ISCHEMIA–REPERFUSION.Conclusion: It was demonstrated that PM10 increases MDA, as well as the percentage of cardiac INFARCT SIZE, and has negative effects on HEMODYNAMIC PARAMETERS. This study suggests that vanillic acid may serve as an adjunctive treatment in delaying the progression of ischemic heart disease.

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APA: Copy

Radmanesh, Esmat, DIANAT, MAHIN, BADAVI, MOHAMMAD, GOUDARZI, GHOLAMREZA, & MARD, SEYYED ALI. (2017). THE CARDIOPROTECTIVE EFFECT OF VANILLIC ACID ON HEMODYNAMIC PARAMETERS, MALONDIALDEHYDE, AND INFARCT SIZE IN ISCHEMIA-REPERFUSION ISOLATED RAT HEART EXPOSED TO PM₁₀. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(7), 761-769. SID. https://sid.ir/paper/695815/en

Vancouver: Copy

Radmanesh Esmat, DIANAT MAHIN, BADAVI MOHAMMAD, GOUDARZI GHOLAMREZA, MARD SEYYED ALI. THE CARDIOPROTECTIVE EFFECT OF VANILLIC ACID ON HEMODYNAMIC PARAMETERS, MALONDIALDEHYDE, AND INFARCT SIZE IN ISCHEMIA-REPERFUSION ISOLATED RAT HEART EXPOSED TO PM₁₀. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(7):761-769. Available from: https://sid.ir/paper/695815/en

IEEE: Copy

Esmat Radmanesh, MAHIN DIANAT, MOHAMMAD BADAVI, GHOLAMREZA GOUDARZI, and SEYYED ALI MARD, “THE CARDIOPROTECTIVE EFFECT OF VANILLIC ACID ON HEMODYNAMIC PARAMETERS, MALONDIALDEHYDE, AND INFARCT SIZE IN ISCHEMIA-REPERFUSION ISOLATED RAT HEART EXPOSED TO PM₁₀,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 7, pp. 761–769, 2017, [Online]. Available: https://sid.ir/paper/695815/en

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