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Cites:

1

Information Journal Paper

Title

FINITE ELEMENT ANALYSIS OF TISSUE CONDUCTIVITY DURING HIGH-FREQUENCY AND LOW-VOLTAGE IRREVERSIBLE ELECTROPORATION

Pages

  135-140

Abstract

 Introduction: I rreversible ELECTROPORATION (IRE) is a process in which the membrane of the cancer cells are irreversibly damaged with the use of high-intensity electric pulses, which in turn leads to cell death. The IRE is a non-thermal way to ablate the cancer cells. This process relies on the distribution of the electric field, which affects the pulse amplitude, width, and electrical conductivity of the tissues. The present study aimed to investigate the relationship of the pulse width and intensity with the conductivity changes during the IRE using simulation.Materials and Methods: For the purpose of the study, the COMSOL 5 software was utilized to predict the conductivity changes during the IRE. We used 4, 000 bipolar and monopolar pulses with the frequency of 5 kHz and 1 Hz, width of 100 ms, and electric fields of low and high intensity. Subsequently, we built three-dimensional numerical models for the liver tissue.Results: The results of our study revealed that the conductivity of tissue increased during the application of electrical pulses. Additionally, the conductivity changes increased with the elevation of the electric field intensity.Conclusion: As the finding of this study indicated, the IRE with high-frequency and low electric field intensity could change the tissue conductivity. Therefore, the IRE was recommended to be applied with HIGH FREQUENCY and LOW VOLTAGE.

Cites

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    • Cite

    APA: Copy

    KHORASANI, AMIR, FIROOZABADI, SEYED MOHAMMAD, & SHANKAYI, ZEINAB. (2017). FINITE ELEMENT ANALYSIS OF TISSUE CONDUCTIVITY DURING HIGH-FREQUENCY AND LOW-VOLTAGE IRREVERSIBLE ELECTROPORATION. IRANIAN JOURNAL OF MEDICAL PHYSICS, 14(3), 135-140. SID. https://sid.ir/paper/695900/en

    Vancouver: Copy

    KHORASANI AMIR, FIROOZABADI SEYED MOHAMMAD, SHANKAYI ZEINAB. FINITE ELEMENT ANALYSIS OF TISSUE CONDUCTIVITY DURING HIGH-FREQUENCY AND LOW-VOLTAGE IRREVERSIBLE ELECTROPORATION. IRANIAN JOURNAL OF MEDICAL PHYSICS[Internet]. 2017;14(3):135-140. Available from: https://sid.ir/paper/695900/en

    IEEE: Copy

    AMIR KHORASANI, SEYED MOHAMMAD FIROOZABADI, and ZEINAB SHANKAYI, “FINITE ELEMENT ANALYSIS OF TISSUE CONDUCTIVITY DURING HIGH-FREQUENCY AND LOW-VOLTAGE IRREVERSIBLE ELECTROPORATION,” IRANIAN JOURNAL OF MEDICAL PHYSICS, vol. 14, no. 3, pp. 135–140, 2017, [Online]. Available: https://sid.ir/paper/695900/en

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